139717-63-8

Upstream product

• 139717-62-7 N-tosyl-2-(2-acetoxy-1-isopropylthioethyl)-6-methoxyanilide 
• 98-59-9 p-toluenesulfonyl chloride 
• 3189-22-8 7-methoxy-1H-indole 
• 53055-05-3 3-methoxy 2-nitrobenzaldehyde 
• 894810-79-8 N-p-toluenesulfonyl-2-ethenyl-6-methoxyaniline 
• 894810-40-3 N-allyl-N-(2-methoxy-6-vinyl-phenyl)-4-methyl-benzenesulfonamide 
• 139717-72-9 2-(2-acetoxy-1-isopropylthioethyl)-6-methoxyaniline 
• 90-04-0 2-methoxy-phenylamine 
• 150330-40-8 2-Methoxy-6-vinyl-1-nitrobenzene 

Downstream Products

• 927427-86-9 C₁₆H₁₄N₂O₅S 

Relevant academic research and scientific papers

IMIDAZOLE DERIVATIVES AS FUNCTIONALLY SELECTIVE ALPHA2C ADRENORECEPTOR AGONISTS

In its many embodiments, the present invention provides imidazole derivatives which are inhibitors of alPha2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition or amelioration of one or more conditions associated with the alpha2C adrenergic receptors using such compounds or pharmaceutical compositions. Formula (I).

Development of isomerization and cycloisomerization with use of a ruthenium hydride with N-heterocyclic carbene and its application to the synthesis of heterocycles

A pure ruthenium hydride complex with N-heterocyclic carbene (NHC) ligand was efficiently generated from the reaction of a second-generation Grubbs ruthenium catalyst with vinyloxytrimethylsilane and unambiguously characterized. This ruthenium hydride complex showed high catalytic activity for the selective isomerization of terminal olefin and for the cycloisomerization of 1,6-dienes. These reactions of N-allyl-o-vinylaniline lead to novel synthetic methods for heterocycles such as indoles and 3-methylene-2,3-dihydroindoles, which are useful synthons for bioactive natural products. These procedures address an important issue in diversity-oriented synthesis.

SYNTHESIS OF 4-, 5-, 6- AND 7-SUBSTITUTED N-TOSYLINDOLES FROM SUBSTITUTED ANILINES

4-, 5-, 6-, and 7-Substituted N-tosylindoles are prepared from N-tosylanilides, carrying 2-acetoxy-1-(isopropylthio)ethyl group at the ortho position, which can be prepared from substituted anilines and dialkyl sulfide by sigmatropic rearrangement.