3189-22-8

Basic information

• Product Name: 7-Methoxy-1H-indole
• Synonyms: METHOXYINDOLE(7-);7-METHOXYINDOLE;7-METHOXY-1H-INDOLE;7-METHOYINDOLE;7-METHOYINDOLE - REGULATED;7-METHOXY ISOFLAVONE;NSC 100739;7-Methoxyindole ,98%
• CAS NO: 3189-22-8
• Molecular Formula: C₉H₉NO
• Molecular Weight: 147.17
• EINECS: 221-690-1
• Product Categories: blocks;IndolesOxindoles;Indoles and derivatives;Pyrroles & Indoles;Indoline & Oxindole;Indoles;Simple Indoles;Indole;Pyrroles & Indoles;Building Blocks;Heterocyclic Building Blocks;Heterocycle-Indole series
• Mol File: 3189-22-8.mol
• Article Data: 22

Chemical Properties

• Melting Point: 147-150°C
• Boiling Point: 108-110 °C0.3 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Pale yellow to brown/Liquid
• Density: 1.126 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00234mmHg at 25°C
• Refractive Index: n20/D 1.612(lit.)
• Storage Temp.: −20°C
• PKA: 16.49±0.30(Predicted)
• CAS DataBase Reference: 7-Methoxy-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Methoxy-1H-indole(3189-22-8)
• EPA Substance Registry System: 7-Methoxy-1H-indole(3189-22-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36-39
• WGK Germany: 3
• HazardClass: LIGHT SENSITIVE, KEEP COLD
• Hazardous Substances Data: 3189-22-8(Hazardous Substances Data)

Usage

Chemical Properties

Pale brown to brown liquid

InChI:InChI=1/C9H9NO/c1-11-8-4-2-3-7-5-6-10-9(7)8/h2-6,10H,1H3

Upstream product

• 24610-33-1 7-methoxy-1H-indole-2-carboxylic acid 
• 16990-40-2 1-(2-nitro-3-methoxyphenyl)-2-nitroethene 
• 105896-38-6 N-(2-methoxyphenyl)ethenesulfinamide 
• 34158-94-6 acetaldehyde o-methoxyphenylhydrazone 
• 75-52-5 nitromethane 
• 591-31-1 3-methoxy-benzaldehyde 
• 96096-68-3 β-pyrrolidino-2-nitro-3-methoxystyrene 
• 90-04-0 2-methoxy-phenylamine 
• 75-07-0 acetaldehyde 
• 6627-53-8 1-chloro-3-methoxy-4-nitrobenzene 
• 611-07-4 5-chloro-2-nitrophenol 
• 104682-96-4 2,3-dihydro-7-iodoindole 
• 104682-95-3 1-acetyl-2,3-dihydro-7-iodoindole 
• 16078-30-1 1-Acetyl-2,3-dihydro-1H-indole 

Downstream Products

• 861385-81-1 3-chloro-8-methoxy-quinoline 
• 109021-59-2 7-methoxy-1H-indole-3-carbaldehyde 
• 46388-50-5 (7-methoxy-1H-indol-3-yl)-N,N-dimethylmethanamine 
• 50656-47-8 7-methoxyindole-3-glyoxyl chloride 
• 146073-32-7 7-(methyloxy)-1-(phenylsulfonyl)-1H-indole 
• 480435-88-9 2,5-dichloro-3-(7-methoxy-1H-indol-3-yl)[1,4]benzoquinone 
• 890408-46-5 4-(7-methoxy-1H-indol-3-yl)butan-2-one 
• 96096-67-2 N-(benzyloxycarbonyl)-7-methoxytryptamine 
• 1095885-71-4 4-[7-(methyloxy)-1H-indol-1-yl]benzamide 
• 639068-82-9 N-cyclohexylmethyl-7-methoxyindole 
• 153276-70-1 methyl 7-(methyloxy)-1-(phenylsulfonyl)-1H-indole-4-carboxylate 
• 1347685-35-1 2-(4-benzylpiperidin-1-yl)-1-(7-hydroxy-1H-indol-3-yl)ethanone 
• 1347685-29-3 1-(4-benzylpiperidin-1-yl)-2-(7-methoxy-1H-indol-3-yl)ethane-1,2-dione 
• 1347685-44-2 1-(4-benzylpiperidin-1-yl)-2-(7-hydroxy-1H-indol-3-yl)ethane-1,2-dione 

Relevant articles and documents

Mechanochemical Transformation of CF3 Group: Synthesis of Amides and Schiff Bases

We communicate two mild, solvent-free mechanochemical coupling transformations of CF3 group with nitro compounds into amides or Schiff bases employing Ytterbia as a catalyst. This process proceeds via C?F bond activation, accompanied with utilisation of Si-based reductants/oxygen scavengers – reductants of the nitro group. The scope and limitations of the disclosed methodologies are thoroughly studied. To the best of our knowledge, this work is the first example of mechanical energy promoted transformation of the inert CF3 group into other functionalities. (Figure presented.).

A indole compound and its preparation method and application (by machine translation)

The invention discloses a indole compound and its preparation method and application. The indole compounds of the structural formula such as formula (I) is shown. The indoles, rice galenical demonstrate the excellent inhibitory activity, the effect of most of the compound is obviously better than the positive control drug validamycin; especially compound I - 43, I - 44, I - 54, I - 73, II - 7 and II - 17, its galenical very good living body protection and treating effect, effect is better than the positive control; more specifically, compound I - 43 of the rice sheath blight bacteriostatic activity than validamycin activity is improved by nearly 300 times. The indole compounds in the prevention and/or treatment of rice sheath blight has great application prospects. In addition the compound of the invention is simple in construction, the preparation method is simple, and is suitable for large-scale industrial production. (I). (by machine translation)

Studies of new indole alkaloid coupling methods for the synthesis of haplophytine

The two novel bisindole alkaloid structures shown can be synthesized in a few steps from the canthiphytine derivative 9.