139722-34-2

Upstream product

• 118-48-9 isatoic anhydride 
• 123-11-5 4-methoxy-benzaldehyde 
• 1904-58-1 anthranilic acid hydrazide 
• 836-41-9 p-methoxybenzylidene-phenylamine 

Downstream Products

• 69722-15-2 3-(4-methoxybenzylideneamino)-2-(4-methoxyphenyl)-quinazolin-4(3H)-one 

Relevant academic research and scientific papers

Synthetic method of quinazolinone Schiff base compounds

The invention discloses a synthetic method of quinazolinone Schiff base compounds. The synthetic method comprises the following steps: 1, raw materials including isatoic anhydride, carbonyl containing compounds and hydrazine hydrate are weighed in the mole ratio being 1:(2-2.2):1; 2, the raw materials weighed in the step 1 are mixed in a solvent, and the mixture is subjected to a heating reflux reaction with a nanometer metal oxide as a catalyst; 3, reaction products obtained in the step 2 are separated and purified, and the quinazolinone Schiff base compounds are obtained. With the adoption of the synthetic method, poisonous solvents and acid and alkaline conditions used in current synthetic reactions are avoided, reaction steps are reduced, and the reaction yield is increased.

Synthesis and properties of 1,2-dihydro-4(3H)-quinazolinones

We modified the preparative-scale method for the synthesis of 2-aryl 1,2-dihydro-4(3H)-quinazolinone derivatives obtained in high yields by the reaction of new and commercially available aromatic aldehydes with anthranilic acid amides. A series of quinazolinone derivatives possessing anticancer and antiparasitic activities, as well as capable of preventing the progress of neurodegenerative diseases were characterized. There are grounds for clinical trials of these substances in order to select compounds being promising for clinical application.

An efficient nano CuO-catalyzed synthesis and biological evaluation of quinazolinone Schiff base derivatives and bis-2,3-dihydroquinazolin-4(1H)-ones as potent antibacterial agents against Streptococcus lactis

An environmentally benign nano CuO catalyzed strategy has been developed for one-pot synthesis of quinazolinone Schiff base derivatives and bis-2,3-dihydroquinazolin-4(1H)-ones by use of hydrazine hydrate and ethidene diamine as nitrogen source. The antib

Combinatorial synthesis of 3-arylideneaminoquinazolin-4(1H)-one derivatives catalyzed by iodine in ionic liquids

A combinatorial synthesis of 3-arylideneaminoquinazolin-4(1H)-one derivatives is described by a reaction of 2-aminobenzohydrazides with two equivalents of aldehydes or ketones in ionic liquids catalyzed by iodine. Controlling the reaction temperature or r

Formation of 1,2-Dihydroquinazolin-4(3H)-ones. Reinvestigation of a Recently Reported 1,3,4-Benzotriazepine Synthesis

A recent paper (Bull.Chem.Soc.Jpn. 59, 1575/1986/) reported that the reactions of o-aminobenzoylhydrazine with benzylideneanilines lead to the formation of 1,3,4-benzotriazepin-5-one or 1-(o-benzylideneaminobenzoyl)-2-benzylidenehydrazines, depending on the substituents used.This is shown by the present paper to be incorrect.Depending on the proportions of the reagents, the above reactions lead to 1-(o-aminobenzoyl)-2-benzylidenehydrazines (7) or 2-aryl-3-benzylideneamino-1,2-dihydroquinazolin-4(3H)-ones (8).