139727-33-6Relevant academic research and scientific papers
Structure-Activity Relationships of the Antimalarial Agent Artemisinin. 1. Synthesis and Comparative Molecular Field Analysis of C-9 Analogs of Artemisinin and 10-Deoxoartemisinin
Avery, Mitchell A.,Gao, Fenglan,Chong, Wesley K. M.,Mehrotra, Sanjiv,Milhous, Wilbur K.
, p. 4264 - 4275 (2007/10/02)
A series of C-9 β-substituted artemisinin analogs (2-21) were synthesized via dianion alkylation of the total synthetic intermediate 57 followed by subsequent ozonolysis/acidification, or by alkylation of the enolate derived from (+)-9-desmethylartemisini
Antimalarial analogs of artemisinin
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, (2008/06/13)
Polyoxoheterocyclic tetracycles related to the Chinese antimalarial natural product qinghaosu (artemisinin) are disclosed. These materials have a STR1 core structure with an oxygen (carbonyl or alkyl ether) at position 12 and in some cases one or two alkyl or aralkyl substituents at position 11. These materials have antimalarial properties.
