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Relevant academic research and scientific papers

Synthesis, characterization and antimicrobial activity of 4-((1-benzyl/phenyl-1H-1,2,3-triazol-4-yl)methoxy)benzaldehyde analogues

A diverse series of 4-((1-benzyl/phenyl-1H-1,2,3-triazol-4-yl)methoxy)benzaldehyde analogues has been synthesized in good yield by the click reaction between 4-O-propargylated benzaldehyde and various organic bromides/azides. All the synthesized compounds

Synthesis, antimicrobial evaluation and docking study of triazole containing triaryl-1H-imidazole

An efficient route for the synthesis of triazole containing triaryl-1H-imidazole (3a–3r) was achieved involving multicomponent condensation of triazole aldehydes, ammonium acetate and 1,2-dicarbonyl compounds in glacial acetic acid. The structure of newly synthesized imidazoles was established by the FTIR, HRMS and NMR spectra. All the compounds displayed considerable antimicrobial activity against fungal and bacterial strains. The triazolyl imidazole 3p was substantially potent against P. aeruginosa (0.0113 μmol/mL), A. niger (0.0113 μmol/mL) and C. albicans (0.0056 μmol/mL) wherein triazolyl imidazoles 3i was found to be more potent against B. subtilis (0.0122 μmol/mL) & A. niger (0.0121 μmol/mL); and compound 3r was also found to be more potent against S. epidermidis (0.0117 μmol/mL) & C. albicans (0.0058 μmol/mL). As a result of docking studies, the binding affinity of the compound 3o was –9.6 kcal/mol which was even more in comparison to the binding affinity of co-crystallized ligand CBN (–9.4 kcal/mol).

Design and synthesis of imidazolo-1, 2,3-triazoles hybrid compounds by microwave-assisted method: Evaluation as an antioxidant and antimicrobial agents and molecular docking studies

The present manuscript describes synthesis of a new class of antimicrobial and antioxidant agents (imidazole linked 1,2,3-triazole hybrid compounds) and screened for their in-vitro studies for antimicrobial and antioxidant activity. In the present investigation, We have developed a simple and convenient method to design and synthesize imidazole linked mono-triazole (6) as well as imidazole linked bis-triazole (9) derivatives by using the click reaction followed by multi component reaction for compounds (6) and vice-versa for the synthesis of compounds (9). The reactions were carried out by two different techniques, conventional heating and microwave irradiation. Microwave irradiation method offers excellent yields, lesser reaction times and environmental friendly reactions. These compounds were studied for their antimicrobial, antioxidant and molecular docking studies using Schrodinger suite. For their in-vitro antimicrobial activity against gram-positive, gram-negative strains; preliminary results indicated that some target compounds exhibited promising antimicrobial potency especially 6c, 6h, 9d, 9e and 9h. Further these compounds were tested for their in-vitro antioxidant activity using four different methods few of them are exhibited excellent antioxidant activity especially 6d, 6h, 9a, 9c, 9e, 9f, 9h. In addition these compounds activity relationship were further supported by in-silico molecular docking studies some of the active compounds 6c, 6h, 9d and 9e showed maximum dock score.

Facile and highly efficient procedure for the synthesis of triazolyl methoxyphenyl 1,8-dioxo-decahydroacridines via one-pot, pseudo-five-component reaction

A series of triazolyl methoxyphenyl 1,8-dioxo-decahydroacridine derivatives has been prepared in a one-pot, pseudo-five-component reaction of aromatic propargylated aldehydes, various azides, dimedone, and a variety of amines in the presence of Cu(OAc)2/sodium ascorbate and 1-methylimidazolium trifluoroacetate ([Hmim]TFA) as the catalyst in good yields.