1397293-28-5

Basic information

• Product Name: 4-nitrophenyl (1-([1,1'-biphenyl]-3-yl)cyclopropyl)carbamate
• Synonyms: 4-nitrophenyl (1-([1,1'-biphenyl]-3-yl)cyclopropyl)carbamate
• CAS NO: 1397293-28-5
• Molecular Weight: 374.396
• Mol File: 1397293-28-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-nitrophenyl (1-([1,1'-biphenyl]-3-yl)cyclopropyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-nitrophenyl (1-([1,1'-biphenyl]-3-yl)cyclopropyl)carbamate(1397293-28-5)
• EPA Substance Registry System: 4-nitrophenyl (1-([1,1'-biphenyl]-3-yl)cyclopropyl)carbamate(1397293-28-5)

Safety Data

• Hazardous Substances Data: 1397293-28-5(Hazardous Substances Data)

Upstream product

• 24973-50-0 3-phenylbenzonitrile 
• 1266158-17-1 C₁₅H₁₅N 
• 7693-46-1 4-Nitrophenyl chloroformate 

Downstream Products

• 1397293-31-0 5-(3-(1-([1,1‘-biphenyl]-3-yl)cyclopropyl)ureido)-2-chlorobenzamide 

Relevant articles and documents

Selective and potent urea inhibitors of cryptosporidium parvum inosine 5′-monophosphate dehydrogenase

Cryptosporidium parvum and related species are zoonotic intracellular parasites of the intestine. Cryptosporidium is a leading cause of diarrhea in small children around the world. Infection can cause severe pathology in children and immunocompromised patients. This waterborne parasite is resistant to common methods of water treatment and therefore a prominent threat to drinking and recreation water even in countries with strong water safety systems. The drugs currently used to combat these organisms are ineffective. Genomic analysis revealed that the parasite relies solely on inosine-5′-monophosphate dehydrogenase (IMPDH) for the biosynthesis of guanine nucleotides. Herein, we report a selective urea-based inhibitor of C. parvum IMPDH (CpIMPDH) identified by high-throughput screening. We performed a SAR study of these inhibitors with some analogues exhibiting high potency (IC50 1000-fold versus human IMPDH type 2 and good stability in mouse liver microsomes. A subset of inhibitors also displayed potent antiparasitic activity in a Toxoplasma gondii model.