139758-84-2

Basic information

• Product Name: (R,R)-(+)-2-methoxy-2-phenylethyl 2-methyl-4-<3,4-(methylenedioxy)phenyl>-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
• CAS NO: 139758-84-2
• Molecular Weight: 461.514
• Mol File: 139758-84-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R,R)-(+)-2-methoxy-2-phenylethyl 2-methyl-4-<3,4-(methylenedioxy)phenyl>-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (R,R)-(+)-2-methoxy-2-phenylethyl 2-methyl-4-<3,4-(methylenedioxy)phenyl>-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate(139758-84-2)
• EPA Substance Registry System: (R,R)-(+)-2-methoxy-2-phenylethyl 2-methyl-4-<3,4-(methylenedioxy)phenyl>-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate(139758-84-2)

Safety Data

• Hazardous Substances Data: 139758-84-2(Hazardous Substances Data)

Upstream product

• 17628-72-7 R-(-)-2-methoxy-2-phenyl ethanol 
• 611-71-2 (R)-Mandelic Acid 
• 611-71-2 MANDELIC ACID 
• 3966-32-3 (R)-methoxyphenylacetic acid 
• 7021-09-2 rac-methoxyphenylacetic acid 
• 120-57-0 piperonal 
• 504-02-9 1,3-cylohexanedione 
• 104451-36-7 (R)-(-)-2-methoxy-2-phenylethyl acetoacetate 

Downstream Products

• 139758-86-4 (R)-(+)-methyl 2-methyl-4-<3,4-(methylenedioxy)phenyl>-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate 

Relevant articles and documents

Synthesis, Configuration, and Calcium Modulatory Properties of Enantiomerically Pure 5-Oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylates

Enantiomerically pure hexahydroquinolinones of the structural type 9 were prepared by a variation of the Hantzsch synthesis in which an optically active acetoacetate served as a chiral auxiliary reagent.Determination of the de and ee values are described.The absolute configurations of the optically pure products were characterized by single-crystal X-ray analysis.The antipodes 9a and 9b exhibited calcium antagonistic activities on smooth musculature; the (S)-(-)-enantiomer 9b was the more potent compound with regard to the EC50 values which differed by a factor of 100; the intrinsic axctivity of 9b was 1.2, compared with a value of 0.54 for 9a.On the other hand, R-(+)-9a exerted positive inotropic effects on electrically stimulated atria.The cause of these effects is discussed.