139758-86-4

Basic information

• Product Name: methyl 2-methyl-4-(3,4-(methylenedioxy)phenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
• Synonyms: methyl 2-methyl-4-(3,4-(methylenedioxy)phenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
• CAS NO: 139758-86-4
• Molecular Formula: C19H19 N O5
• Molecular Weight: 0
• Mol File: 139758-86-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 511.7°C at 760 mmHg
• Flash Point: 263.2°C
• Appearance: /
• Density: 1.35g/cm³
• Vapor Pressure: 1.39E-10mmHg at 25°C
• Refractive Index: 1.621
• CAS DataBase Reference: methyl 2-methyl-4-(3,4-(methylenedioxy)phenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-methyl-4-(3,4-(methylenedioxy)phenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate(139758-86-4)
• EPA Substance Registry System: methyl 2-methyl-4-(3,4-(methylenedioxy)phenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate(139758-86-4)

Safety Data

• Hazardous Substances Data: 139758-86-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C19H19NO5/c1-10-16(19(22)23-2)17(18-12(20-10)4-3-5-13(18)21)11-6-7-14-15(8-11)25-9-24-14/h6-8,17,20H,3-5,9H2,1-2H3

Upstream product

• 67-56-1 methanol 
• 139758-84-2 (R,R)-(+)-2-methoxy-2-phenylethyl 2-methyl-4-<3,4-(methylenedioxy)phenyl>-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate 

Relevant articles and documents

Synthesis, Configuration, and Calcium Modulatory Properties of Enantiomerically Pure 5-Oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylates

Enantiomerically pure hexahydroquinolinones of the structural type 9 were prepared by a variation of the Hantzsch synthesis in which an optically active acetoacetate served as a chiral auxiliary reagent.Determination of the de and ee values are described.The absolute configurations of the optically pure products were characterized by single-crystal X-ray analysis.The antipodes 9a and 9b exhibited calcium antagonistic activities on smooth musculature; the (S)-(-)-enantiomer 9b was the more potent compound with regard to the EC50 values which differed by a factor of 100; the intrinsic axctivity of 9b was 1.2, compared with a value of 0.54 for 9a.On the other hand, R-(+)-9a exerted positive inotropic effects on electrically stimulated atria.The cause of these effects is discussed.