139764-32-2Relevant academic research and scientific papers
Supramolecular asymmetric induction with a NADH model reagent grafted on silica
Losset, D.,Dupas, G.,Duflos, J.,Bourguignon, J.,Queguiner, G.
, p. 721 - 729 (2007/10/02)
A model of NADH issued from a thieno dihydropyridine derivative has been grafted onto a silica matrix bearing on another part a chiral auxiliary.Two strategies were implemented to obtain the corresponding reagents.In the first case, the reagent and the auxiliary were grafted to the silica by means of two different arms.In the second case, the reagent and the auxiliary were linked to two arms which are brought together before beiing linked to the silica matrix.The reagents thus obtained were involved in the reduction of methyl phenyl glyoxylate and enantiomeric excesses of 20 and 35percent were obtained.Key words: NADH models / grafting on silica / supramolecular induction
