1397682-61-9

Usage

Uses

Used in Bioconjugation:
Propargyl-PEG5-tetra-Ac-beta-D-galactose is used as a crosslinker for bioconjugation, allowing the selective and stable attachment of biomolecules, such as proteins or nucleic acids, through Click Chemistry. This application is particularly useful in the development of targeted drug delivery systems, biosensors, and diagnostic tools.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Propargyl-PEG5-tetra-Ac-beta-D-galactose is used as a component in the design of drug delivery systems. Its ability to form stable linkages with drug molecules or carriers through Click Chemistry enables the development of more effective and targeted therapies with improved bioavailability and reduced side effects.
Used in Material Science:
In the field of material science, Propargyl-PEG5-tetra-Ac-beta-D-galactose is used as a building block for the creation of novel biocompatible materials. Its unique structure allows for the formation of complex networks and hydrogels with tailored properties, which can be applied in tissue engineering, wound healing, and other biomedical applications.
Used in Chemical Synthesis:
Propargyl-PEG5-tetra-Ac-beta-D-galactose serves as a valuable intermediate in chemical synthesis, particularly for the development of complex organic molecules and macromolecules. Its Click Chemistry-ready propargyl group and D-galactose functionality make it an attractive candidate for the synthesis of new compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 87450-10-0 3,6,9,12-tetraoxapentadec-14-yn-1-ol 
• 14199-53-2 peracetylated β-D-glucose 
• 4163-60-4 β-D-galactose peracetate 
• 112-60-7 Tetraethylene glycol 
• 25878-60-8 D-galactose pentaacetate 

Downstream Products

• 1360446-35-0 C₄₅H₅₁N₅O₁₇*C₈₂H₁₀₂N₁₀O₃₂ 
• 1397682-63-1 {2-[2-(2-(2-propyn-1-yloxy)ethoxy)ethoxy]ethoxy}ethyl-β-D-galactopyranoside 

Relevant academic research and scientific papers

Click Chemistry-Assisted Synthesis of a β- D -Galactose-Targeted SiO2@RC Shell-Core Structure as a Nanoplatform for Metal-Based Complex Delivery

A facile reversed-phase microemulsion method was used to synthesize shell-core nanospheres of SiO2@RCs (SiO2-encapsuled rare-earth metal complexes). β-d-Galactose was then grafted onto the surfaces of the nanospheres through the copper(I)-catalyzed azide-alkyne cycloaddition click reaction for targeted delivery. The chemical characteristics and surface profiles of the nanocarriers were investigated by Fourier transform infrared spectroscopy, dynamic light scattering, transmission electron microscopy, and scanning electron microscopy. A high-efficiency microwave synthesis method was applied to prepare five complex cores by the reaction of different rare-earth metal salts with two isomeric ligands, o-CPA (2-chlorophenoxyacetic acid) and m-CPA (3-chlorophenoxyacetic acid). The crystal structures of the five synthesized RC cores were confirmed through X-ray diffraction, which revealed the formulas of five RCs, [Dy(o-CPA)3(H2O)]·H2O RC1, [Ho(o-CPA)3(H2O)]·H2O RC2, 2[Er(m-CPA)3(H2O)]·3H2O RC3, 2[Gd(m-CPA)3(H2O)]·3H2O RC4, and [Ce2(m-CPA)6(H2O)3]·2H2O RC5. An in vitro cell study revealed that all RCs exhibited certain anticancer activities. RC2, in particular, showed the strongest cytotoxicity against HepG2 cells. The enhanced cell permeability and drug retention considerably improved the cytotoxicity of all SiO2@RC2-gal relative to that of RC2. The selective uptake of the β-d-galactose-conjugated nanospheres by HepG2 cells through mechanisms mediated by cell surface receptors resulted in fewer side effects on extrahepatic tissues. Our contribution provides a novel design concept of a target SiO2@RCs-gal nanocarrier for delivering affordable antitumor complexes in cancer therapy.

Mimicking biological membranes with programmable glycan ligands self-assembled from amphiphilic Janus glycodendrimers

An accelerated modular synthesis produced 18 amphiphilic Janus glycodendrimers with three different topologies formed from either two or one carbohydrate head groups or a mixed constellation with a noncarbohydrate hydrophilic arm. By simple injection of their THF solutions into water or buffer, all of the Janus compounds self-assembled into uniform, stable, and soft unilamellar vesicles, denoted glycodendrimersomes. The mixed constellation topology glycodendrimersomes were demonstrated to be most efficient in binding plant, bacterial, and human lectins. This evidence with biomedically relevant receptors offers a promising perspective for the application of such glycodendrimersomes in targeted drug delivery, vaccines, and other areas of nanomedicine.

Second generation specific-enzyme-activated rotaxane propeptides

A [2]rotaxane, in which the peptidic axle is protected from degradation by the macrocyclic sheath and terminated with a novel glycosidase-cleavable stopper, is rendered water-soluble by derivatisation with tetra(ethylene glycol) (TetEG) or glucosylated te