1397689-52-9Relevant academic research and scientific papers
NOVEL IODINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND USE THEREOF AS AMINATION AGENTS
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Page/Page column 67-68, (2012/12/13)
The iodine compounds of the present invention corresponds to those of formula (I), wherein R1, R1' and X have several meanings. These iodine compounds gives rise to the amination of several substrates without the need of catalysts, especially metal catalysts, and confer to the amination reaction the further advantage of being performed under mild conditions, which is of interest for industrial-scale production of nitrogenated compounds with pharmaceutical, biological or medicinal applications. Therefore, the iodine compounds of the invention are useful as amination agents. The invention also discloses several processes for the preparation of the iodine compounds of formula (I).
Metal-free iodine(III)-promoted direct intermolecular C-H amination reactions of acetylenes
Souto, Jose A.,Becker, Peter,Iglesias, Alvaro,Muniz, Kilian
supporting information, p. 15505 - 15511 (2012/10/29)
A direct metal-free amination of arylalkynes has been developed, which proceeds by reaction of the terminal alkyne with the hypervalent iodine reagent PhI(OAc)NTs2 within a single-step operation. This unprecedented intermolecular C-H to C-N bond conversion provides rapid access to the important class of ynamides. In addition to the title reaction, the related transformation between alkylated alkynes and the iodine(III) reagent is also discussed.
