1397692-03-3

Upstream product

• 1397692-00-0 N-(2-benzyl-8-methoxybenzo[f]quinoxalin-3-yl)acetamide 
• 1397691-98-3 2-amino-3-benzyl-5-(4-methoxy-2-vinylphenyl)-6-vinylpyrazine 
• 1397691-97-2 2-(5-amino-6-benzyl-3-vinylpyrazin-2-yl)-5-methoxybenzaldehyde 
• 1397691-96-1 2-(5-amino-6-benzyl-3-chloropyrazin-2-yl)-5-methoxybenzaldehyde 
• 1397691-95-0 2-amino-3-benzyl-5-bromo-6-chloropyrazine 
• 1397692-01-1 3-amino-2-benzyl-8-methoxybenzo[f]quinoxaline 
• 1397691-99-4 N-(3-benzyl-5-(4-methoxy-2-vinylphenyl)-6-vinylpyrazin-2-yl)acetamide 

Downstream Products

• 114496-03-6 12-benzyl-8-hydroxy-2-(4-hydroxybenzyl)-11H-benz[f]imidazo[1,2-a]quinoxalin-3-one 
• 1397692-04-4 12-benzyl-8-hydroxy-2-[4-(trifluoromethyl)benzyl]-11H-benz[f]imidazo[1,2-a]quinoxalin-3-one 

Relevant academic research and scientific papers

Concise Synthesis of v-Coelenterazines

A novel synthetic method for v-coelenterazine (v-CTZ), which is a vinylene-bridged analog of native CTZ with a large red-shifted luminescence property, is described. The synthesis was achieved in a concise way through the use of three sequential cross-cou

Method of manufacturing terazine compd. v-

PROBLEM TO BE SOLVED: To provide a method for producing a v-coelenterazine compound.SOLUTION: There is provided a method for producing a v-coelenterazine compound represented by the general formula (II), the method comprising: (1) a step of reacting a compound represented by the general formula (VIII) with a methyltriphenylphosphonium salt in the presence of a base to obtain a compound represented by general formula (IX); (2) a step of performing a ring-closing metathesis reaction on any one selected from the group consisting of the compound represented by general formula (IX) and a compound represented by the general formula (X) in which the amino of the compound represented by the general formula (IX) is protected with Rand then deprotecting R4 and R5 when present to obtain a v-coelenteramine compound represented by the general formula (XIV); and (3) a step of reacting the compound represented by the general formula (XIV) with a compound represented by the general formula (XV) to obtain a compound represented by the general formula (II).

PROCESS FOR PRODUCING v-COELENTERAZINE COMPOUNDS

A simple process for producing v-coelenterazine compounds has been desired. Described is a process for producing a v-coelenterazine compound represented by general formula (II) comprising (1) the step of reacting a compound of general formula (VIII) with a methyltriphenylphosphonium salt in the presence of a base to give a compound represented by general formula (IX), (2) the step of performing a ring-closing metathesis reaction on any one selected from the group consisting of the compound represented by general formula (IX) and a compound of general formula (X) which is the compound of general formula (IX) wherein the amino is protected with R5, and then deprotecting R4 and, if any, R5 to give a v-coelenteramine compound represented by general formula (XIV), and (3) the step of reacting the compound of general formula (XIV) with a compound represented by general formula (XV) to give the compound of general formula (II).