3-amino-2-benzylbenzo[f]quinoxalin-8-ol (14,v-coelenteramine)

Base Information

Chemical Name:3-amino-2-benzylbenzo[f]quinoxalin-8-ol (14,v-coelenteramine)
CAS No.:1397692-03-3
Molecular Formula:C₁₉H₁₅N₃O
Molecular Weight:301.348
Hs Code.:

Synonyms:3-amino-2-benzylbenzo[f]quinoxalin-8-ol (14,v-coelenteramine)

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Chemical Property of 3-amino-2-benzylbenzo[f]quinoxalin-8-ol (14,v-coelenteramine)

Chemical Property:

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Technology Process of 3-amino-2-benzylbenzo[f]quinoxalin-8-ol (14,v-coelenteramine)

There total 7 articles about 3-amino-2-benzylbenzo[f]quinoxalin-8-ol (14,v-coelenteramine) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.5%

: 1397692-01-1
3-amino-2-benzyl-8-methoxybenzo[f]quinoxaline

: 1397692-03-3
3-amino-2-benzylbenzo[f]quinoxalin-8-ol (14,v-coelenteramine)

Guidance literature:: With pyridine hydrochloride; at 190 - 210 ℃; for 1h;

Reference yield:

: 1397691-99-4
N-(3-benzyl-5-(4-methoxy-2-vinylphenyl)-6-vinylpyrazin-2-yl)acetamide

: 1397692-03-3
3-amino-2-benzylbenzo[f]quinoxalin-8-ol (14,v-coelenteramine)

Guidance literature:: Multi-step reaction with 3 steps

1: Hoveyda-Grubbs catalyst second generation / 1,2-dichloro-ethane / 17 h / 90 °C / Inert atmosphere

2: boron trifluoride / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

3: methanol / 14 h / 65 °C

With methanol; boron trifluoride; Hoveyda-Grubbs catalyst second generation; In dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 1397691-95-0
2-amino-3-benzyl-5-bromo-6-chloropyrazine

: 1397692-03-3
3-amino-2-benzylbenzo[f]quinoxalin-8-ol (14,v-coelenteramine)

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium fluoride / bis(η3-allyl-μ-chloropalladium(II)); di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane / water; tetrahydrofuran / 14 h / 20 °C / Inert atmosphere

2.1: tetrabutyl-ammonium chloride / bis-triphenylphosphine-palladium(II) chloride / toluene / 1.5 h / Inert atmosphere; Reflux

3.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

3.2: 1.5 h / 0 - 20 °C / Inert atmosphere

4.1: pyridine / dmap / 1 h / 20 - 60 °C / Inert atmosphere

5.1: Hoveyda-Grubbs catalyst second generation / 1,2-dichloro-ethane / 17 h / 90 °C / Inert atmosphere

6.1: boron trifluoride / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

7.1: methanol / 14 h / 65 °C

With pyridine; methanol; potassium fluoride; n-butyllithium; boron trifluoride; tetrabutyl-ammonium chloride; dmap; bis-triphenylphosphine-palladium(II) chloride; Hoveyda-Grubbs catalyst second generation; bis(η3-allyl-μ-chloropalladium(II)); di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane; In tetrahydrofuran; hexane; dichloromethane; water; 1,2-dichloro-ethane; toluene; 1.1: Suzuki-Miyaura coupling / 2.1: Stille Coupling;