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13977-33-8

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13977-33-8 Usage

General Description

N,N-BIS(2-PHENYL-ETHYL)-N-METHYL-AMINE is a chemical compound with the molecular formula C20H25N. It is commonly used as a reagent in organic synthesis and pharmaceutical manufacturing. N,N-BIS(2-PHENYL-ETHYL)-N-METHYL-AMINE is a tertiary amine, meaning it contains three carbon atoms bonded to a nitrogen atom. It is a clear to pale yellow liquid with a faint amine or fishy odor, and it is insoluble in water but soluble in organic solvents. N,N-BIS(2-PHENYL-ETHYL)-N-METHYL-AMINE is also known by its CAS number 41904-43-6 and is primarily used as a catalyst or intermediate in the production of various pharmaceuticals and other organic compounds. However, it is important to handle this chemical with caution, as it can be harmful if inhaled, swallowed, or comes into contact with the skin.

Check Digit Verification of cas no

The CAS Registry Mumber 13977-33-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,9,7 and 7 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 13977-33:
(7*1)+(6*3)+(5*9)+(4*7)+(3*7)+(2*3)+(1*3)=128
128 % 10 = 8
So 13977-33-8 is a valid CAS Registry Number.
InChI:InChI=1/C17H21N/c1-18(14-12-16-8-4-2-5-9-16)15-13-17-10-6-3-7-11-17/h2-11H,12-15H2,1H3

13977-33-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name N-methyl-2-phenyl-N-(2-phenylethyl)ethanamine

1.2 Other means of identification

Product number -
Other names Methyl-diphenaethyl-amin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:13977-33-8 SDS

13977-33-8Downstream Products

13977-33-8Relevant articles and documents

Structure-Activity Relationship Studies of Pyrimidine-4-Carboxamides as Inhibitors of N-Acylphosphatidylethanolamine Phospholipase D

Mock, Elliot D.,Kotsogianni, Ioli,Driever, Wouter P. F.,Fonseca, Carmen S.,Vooijs, Jelle M.,Den Dulk, Hans,Van Boeckel, Constant A. A.,Van Der Stelt, Mario

, p. 481 - 515 (2021/02/05)

N-Acylphosphatidylethanolamine phospholipase D (NAPE-PLD) is regarded as the main enzyme responsible for the biosynthesis of N-acylethanolamines (NAEs), a family of bioactive lipid mediators. Previously, we reported N-(cyclopropylmethyl)-6-((S)-3-hydroxypyrrolidin-1-yl)-2-((S)-3-phenylpiperidin-1-yl)pyrimidine-4-carboxamide (1, LEI-401) as the first potent and selective NAPE-PLD inhibitor that decreased NAEs in the brains of freely moving mice and modulated emotional behavior [ Mock et al. Nat Chem. Biol., 2020, 16, 667-675 ]. Here, we describe the structure-activity relationship (SAR) of a library of pyrimidine-4-carboxamides as inhibitors of NAPE-PLD that led to the identification of LEI-401. A high-throughput screening hit was modified at three different substituents to optimize its potency and lipophilicity. Conformational restriction of an N-methylphenethylamine group by replacement with an (S)-3-phenylpiperidine increased the inhibitory potency 3-fold. Exchange of a morpholine substituent for an (S)-3-hydroxypyrrolidine reduced the lipophilicity and further increased activity by 10-fold, affording LEI-401 as a nanomolar potent inhibitor with drug-like properties. LEI-401 is a suitable pharmacological tool compound to investigate NAPE-PLD function in vitro and in vivo.

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