139778-27-1

Basic information

• Product Name: 2-Iodo-5-methylbenzenesulfonic acid
• Synonyms: 2-IODO-5-METHYLBENZENESULFONIC ACID DIHYDRATE
• CAS NO: 139778-27-1
• Molecular Formula: C₇H₇IO₃S
• Molecular Weight: 298.09815
• EINECS: -0
• Mol File: 139778-27-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 1.979
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-Iodo-5-methylbenzenesulfonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Iodo-5-methylbenzenesulfonic acid(139778-27-1)
• EPA Substance Registry System: 2-Iodo-5-methylbenzenesulfonic acid(139778-27-1)

Safety Data

• Hazardous Substances Data: 139778-27-1(Hazardous Substances Data)

Usage

General Description

2-Iodo-5-methylbenzenesulfonic acid is a chemical compound used mainly in the field of organic chemistry. It has the molecular formula C7H7IO3S. The chemical is characterized by its aromatic benzene ring backbone, and its molecules are enriched with iodine, methyl, and sulfonic acid functional groups. It plays a significant role as a starting material or intermediate in chemical synthesis, mainly for pharmaceuticals or dyes. The compound is known for its high reactivity, which is largely due to the presence of the iodine atom.

Upstream product

• 624-31-7 4-tolyl iodide 
• 88-44-8 2-Amino-5-methylbenzenesulfonic acid 

Downstream Products

• 1345021-20-6 2-(4-bromophenylsulfanyl)-5-(hydroxycarbony)benzenesulfonamide 
• 1345021-23-9 2-(4-bromophenylsulfanyl)-5-methylbenzenesulfonamide 
• 1345020-93-0 3-(4-bromophenyl)-6-carbamoyl-1,3,2-benzodithiazolium ylide 1,1-dioxide 
• 1345020-92-9 3-(4-bromophenyl)-6-(methoxycarbonyl)-1,3,2-benzodithiazolium ylide 1,1-dioxide 
• 1345021-16-0 3-(4-bromophenyl)-6-(hydroxycarbonyl)-1,3,2-benzodithiazolium ylide 1,1-dioxide 
• 1345020-91-8 3-(4-bromophenyl)-6-methyl-1,3,2-benzodithiazolium ylide 1,1-dioxide 
• 1608-47-5 4-Methyl-1,2-diiodobenzene 
• 152716-92-2 1H-1-(1'-phenylethynyl)-5-methyl-1,2,3-benziodoxathiole 3,3-dioxide 

Relevant articles and documents

Synthesis of 1H-1-(1-Alkynyl)-5-methyl-1,2,3-benziodoxathiole 3,3-Dioxides: Alkynyl(aryl)iodonium Sulfonates with Heterocyclic Iodine

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Switchable Divergent Synthesis in Gold-Catalyzed Difunctionalizations of o-Alkynylbenzenesulfonamides with Aryldiazonium Salts

Gold-catalyzed difunctionalizations of o-alkynylbenzenesulfonamides with aryldiazonium salts are reported herein. Upon irradiation with the blue LEDs, benzosultam products were formed via aminoarylation accompanied by the release of N2. Without irradiatio

Aromatic sulfonation 85. Halogen directing and steric effects in the sulfonation of the twelve halogenotoluenes and some related compounds

The isomer distributions for the sulfonation of the twelve halogenotoluenes and some trisubstituted halogenomethylbenzenes, with both 98.4 percent H2SO4 at 25 deg C and sulfur trioxide in nitromethane at 0 deg C, have been determined and found to be very similar.The predominantly para-directing effect of the halogen substituent dominates over that of the methyl substituent: with the 2-halogenotoluenes, the degree of 5-substitution decreases from >/= 90 percent for the fluoro to 50 percent for the iodo compound.The 2- to 3-sulfonation ratio of the 4-halogenotoluenes strongly increases on going from fluorine (0.5) to iodine (7).The ratio of the partial rate factors for the sulfonation of a halogenobenzene ortho and meta to halogen varies from 17 +/- 1 for the fluoro to 1.5 +/- 0.4 for the iodo substituent.In competition to the sulfonation, 2- and 4-iodotoluene undergo deiodination, The latter process is more important with the 4-isomer and with the protic sulfonating reagent.With the aprotic reagent, the reaction proceeds by direct sulfodeiodination, whereas with the sulfuric acid reagent, it proceeds by initial protiodeiodination and sulfodeprotonation.