1397836-52-0

Basic information

• Product Name: thyl 1-((2'-cyanobiphenyl-4-yl) Methyl)-2H-benziMidazol-2-one-7-carboxylate
• Synonyms: thyl 1-((2'-cyanobiphenyl-4-yl) Methyl)-2H-benziMidazol-2-one-7-carboxylate;ethyl3-((2'-cyanobiphenyl-4-yl)Methyl)-2-oxo-2,3-dihydro-1H-benzo[d]iMidazole-4-carboxylate
• CAS NO: 1397836-52-0
• Molecular Formula: C₂₄H₁₉N₃O₃
• Molecular Weight: 397.42596
• EINECS: -0
• Mol File: 1397836-52-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.34±0.1 g/cm3(Predicted)
• PKA: 11.36±0.30(Predicted)
• CAS DataBase Reference: thyl 1-((2'-cyanobiphenyl-4-yl) Methyl)-2H-benziMidazol-2-one-7-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: thyl 1-((2'-cyanobiphenyl-4-yl) Methyl)-2H-benziMidazol-2-one-7-carboxylate(1397836-52-0)
• EPA Substance Registry System: thyl 1-((2'-cyanobiphenyl-4-yl) Methyl)-2H-benziMidazol-2-one-7-carboxylate(1397836-52-0)

Safety Data

• Hazardous Substances Data: 1397836-52-0(Hazardous Substances Data)

Usage

Uses

Azilsartan Cyano-des-1,2,4-Oxadiazol-5-ol is a metabolite of Azilsartan(A926900). Azilsartan is an analgesic and antiinflammatory drugs containing angiotensin II antagonists.

Upstream product

• 139481-41-7 ethyl 1-[(2'-cyano-[1,1']-biphenyl-4-yl)methyl]-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 

Relevant articles and documents

Synthesis of azilsartan and its selected potential impurities

Synthesis of angiotensin II AT1 receptor antagonist azilsartan is described. The results include reinvestigation of the described process as well as its novel modification. This new process includes transformation of the CN group into amidoxime moiety by aqueous hydroxylamine, its treatment with alkyl chloroformates and a base-initiated cyclization of the formed (alkoxycarbonyl-oxy)carbamimidoyl intermediates. Several so far undescribed side-products were identified and some of them were synthesized and duly characterized as potential impurities.