1398113-65-9Relevant academic research and scientific papers
Rapid access to multi-substituted pyrimido[4,5-b][1,4]diazepine-2,4,6- trione and pyrimido[4,5-b][1,4]diazepine-2,4-dione as novel and versatile scaffolds for drug discovery
Li, Gong,Wang, Xiaowei,Tian, Chao,Zhang, Tongbo,Zhang, Zhili,Liu, Junyi
supporting information, p. 5193 - 5196 (2012/11/07)
A novel pyrimido[4,5-b][1,4]diazepine-2,4,6-trione was synthesized with an efficient strategy. Especially, the key intermediate 2,4-dimethoxypyrimido[4,5- b][1,4]diazepin-6-one was promoted by one pot tandem reduction-cyclization with Na2S2O4. Subsequently, reduction of lactams 6 with LiAlH4 afforded a more flexible scaffold of pyrimidodiazepines. The synthetic strategy was versatile since it facilitated the sequential functionalization on the pyrimidodiazepine at three positions. Thus a convenient and effective method for the rapid preparing of multi-substituted pyrimido[4,5-b][1,4]diazepines was developed.
