1398181-08-2Relevant academic research and scientific papers
Copper-mediated trifluoromethylation of α-diazo esters with TMSCF3: The important role of water as a promoter
Hu, Mingyou,Ni, Chuanfa,Hu, Jinbo
supporting information, p. 15257 - 15260 (2012/10/29)
Copper-mediated trifluoromethylation of α-diazo esters with TMSCF3 reagent has been developed as a new method to prepare α-trifluoromethyl esters. This trifluoromethylation reaction represents the first example of fluoroalkylation of a non-fluorinated carbene precursor. Water plays an important role in promoting the reaction by activating the "CuCF3" species prepared from CuI/TMSCF3/CsF (1.0:1.1:1.1). The scope of this trifluoromethylation reaction is broad, and its efficiency is demonstrated in the synthesis of a variety of aryl-, benzyl-, and alkyl-substituted 3,3,3-trifluoropropanoates.
