1398358-69-4

Usage

General Description

1-p-toluenesulfonyl-3-(4-chlorobutyl)-5-cyanoindole is a chemical compound with a molecular formula of C19H18ClN3O2S. It is an indole derivative with a tosyl group and a cyano group attached to the five-membered ring, as well as a 4-chlorobutyl group linked to the 3-position of the indole ring. 1-p-toluenesulfonyl-3-(4-chlorobutyl)-5-cyanoindole is commonly used in organic synthesis and medicinal chemistry, and it has potential pharmaceutical applications due to its structure and properties. Its specific uses may include its role as a starting material for the synthesis of novel drugs, or as a reagent in the formation of carbon-carbon and carbon-nitrogen bonds. Further research and investigation into the properties and potential applications of 1-p-toluenesulfonyl-3-(4-chlorobutyl)-5-cyanoindole are ongoing.

Upstream product

• 1398358-62-7 3-(4-chlorobutanoyl)-1-tosyl-1H-indole-5-carbonitrile 
• 32685-23-7 5-Cyano-1-(p-toluenesulfonyl)indole 
• 98-59-9 p-toluenesulfonyl chloride 
• 15861-24-2 1H-indole-5-carbonitrile 

Downstream Products

• 163521-12-8 vilazodone 
• 143612-79-7 3-(4-chlorobutyl)-5-cyanoindole 

Relevant academic research and scientific papers

A class of indole derivatives and preparation methods and uses thereof

The present invention relates to the field of medicinal chemistry, discloses a class of indole derivatives and preparation methods and uses thereof. The present invention also discloses a compound comprising the indole structure or a pharmaceutically acce

Indole structure-containing compound or pharmaceutically acceptable salt, preparation method and application thereof

The invention discloses an indole structure-containing compound with a structure as shown in a general formula (I) or pharmaceutically acceptable salt, a preparation method and application thereof. The indole structure-containing compound or the pharmaceu

Phenyl sulfide structure-containing compound or pharmaceutically acceptable salt, preparation method and application thereof

The invention discloses a phenyl sulfide structure-containing compound with a structure as shown in a general formula (I) or pharmaceutically acceptable salt, a preparation method and application thereof. The compound containing the phenyl sulfide structu

Scale-up synthesis of antidepressant drug vilazodone

A scale-up synthesis of antidepressant drug vilazodone was accomplished in five steps. Friedel-Crafts acylation of 1-tosyl-1H-indole-5-carbonitrile with 4-chlorobutyryl chloride, selective deoxygenation in NaBH4/CF 3COOH system coupled with ethyl 5-(piperazin-1-yl)-benzofuran-2- carboxylate hydrochloride, one-step deprotection and esterolysis, and the final ammonolysis led to the target molecule vilazodone in 52.4% overall yield and 99.7% purity. This convenient and economical procedure is remarkably applicable for scale-up production.