32685-23-7

Usage

Molecular Structure

The compound consists of an indole ring with a carbonitrile group attached at the 5-position and a sulfonyl group attached to the indole nitrogen.

Usage

Commonly used as a building block in the synthesis of pharmaceuticals and other organic compounds.

Reactivity

The presence of the sulfonyl group makes it a versatile reagent for various chemical reactions, including nucleophilic substitution, electrophilic aromatic substitution, and cross-coupling reactions.

Applications

Potential applications in medicinal chemistry, agrochemicals, and materials science due to its unique structural and chemical properties.

Safety

Should be handled and used with caution due to its potential toxicity and reactivity.

Upstream product

• 96546-77-9 N-tosyl-5-bromoindole 
• 1616975-03-1 N-(4-cyano-2-ethynylphenyl)-4-methylbenzenesulfonamide 
• 412947-51-4 4-amino-3-ethynylbenzonitrile 
• 450381-20-1 4-amino-3-(2-trimethylsilylethynyl)benzenecarbonitrile 
• 33348-34-4 4-amino-3-iodobenzonitrile 
• 15861-24-2 1H-indole-5-carbonitrile 
• 98-59-9 p-toluenesulfonyl chloride 
• 141-78-6 ethyl acetate 
• 10075-50-0 5-bromo-1H-indole 
• 143-33-9 sodium cyanide 

Downstream Products

• 15861-24-2 1H-indole-5-carbonitrile 
• 1349111-29-0 C₁₉H₁₆N₂O₃S 
• 1235976-72-3 N-(p-toluenesulfonyl)-3-acetyl-5-cyanoindole 
• 1398358-62-7 3-(4-chlorobutanoyl)-1-tosyl-1H-indole-5-carbonitrile 
• 1398358-69-4 1-p-toluenesulfonyl-3-(4-chlorobutyl)-5-cyanoindole 
• 163521-12-8 vilazodone 
• 1349111-30-3 C₂₂H₂₂N₂O₃S 
• 17380-19-7 1-(5-cyano-1H-indol-3-yl)ethanone 
• 1160170-23-9 5-cyano-1-(2-nitrophenyl)-1H-indole 
• 144453-64-5 1-(4-methylphenyl)sulfonylindole-5-carboxaldehyde 

Relevant academic research and scientific papers

A class of indole derivatives and preparation methods and uses thereof

The present invention relates to the field of medicinal chemistry, discloses a class of indole derivatives and preparation methods and uses thereof. The present invention also discloses a compound comprising the indole structure or a pharmaceutically acce

A Series of 2-((1-Phenyl-1H-imidazol-5-yl)methyl)-1H-indoles as Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

Indoleamine 2,3-dioxygenase 1 (IDO1) is a promising therapeutic target in cancer immunotherapy and neurological disease. Thus, searching for highly active inhibitors for use in human cancers is now a focus of widespread research and development efforts. I

EIF4E INHIBITORS AND USES THEREOF

The present invention provides compounds inhibiting elF4E activity and compositions and methods of using thereof.

Iodine-Mediated Electrochemical C(sp2)-H Amination: Switchable Synthesis of Indolines and Indoles

A metal-free electrochemical intramolecular C(sp2)-H amination using iodine as a mediator was developed. This method enables a switchable synthesis of indoline and indole derivatives, respectively, from easily available 2-vinyl anilines.

Phenyl sulfide structure-containing compound or pharmaceutically acceptable salt, preparation method and application thereof

The invention discloses a phenyl sulfide structure-containing compound with a structure as shown in a general formula (I) or pharmaceutically acceptable salt, a preparation method and application thereof. The compound containing the phenyl sulfide structu

Indole structure-containing compound or pharmaceutically acceptable salt, preparation method and application thereof

The invention discloses an indole structure-containing compound with a structure as shown in a general formula (I) or pharmaceutically acceptable salt, a preparation method and application thereof. The indole structure-containing compound or the pharmaceu

Electron Transfer Photoredox Catalysis: Development of a Photoactivated Reductive Desulfonylation of an Aza-Heteroaromatic Ring

Herein, we report a protocol for desulfonylation of aza-heteroaromatic rings via photoinduced electron transfer and hydrogen atom transfer. This general protocol has a wide substrate range and moderate to good yields. The utility of the method was demonstrated by the chemoselective desulfonylation of a molecule containing both an aliphatic and an aromatic sulfonamide. (Figure presented.).

A 5 - cyano indole synthesis method (by machine translation)

The invention relates to a 5 - cyano indole synthesis method, through to indole as the starting material, with sodium bisulfite reaction, and then sequentially by acetylation, brominated, protection, [...] and de-protected to obtain 5 - cyano indole. The present invention provides a method of synthesis of the price of raw materials is low cost and easily, thereby reducing the production cost. At the same time the invention synthetic route is short, high yield, high chemical purity of the obtained product, all the reactions are not need special production equipment, and the produced intermediate and final products are not needs the column chromatography and crystallization purification. So the invention not only reduces production cost, convenient for the industrial scale production; and can provide the market with high purity products, obtain the good economic benefits. (by machine translation)

N - substituted benzene sulfonyl -3 - propionyl indole derivatives, preparation method and application

The invention discloses an N-substituted benzenesulfonyl-3-propionyl indole derivative, a preparation method and application and belongs to the technical field of organic synthesis. The structural formula of the N-substituted benzenesulfonyl-3-propionyl i

Preparation method of substituted indoles compounds

The invention belongs to the field of medical technology, and discloses a preparation method of 3-substituted indoles compounds. The preparation method includes using a compound represented by formula (2) as an initial raw material, performing a Friedel-Crafts reaction with 4-chlorobutyryl chloride in the presence of anhydrous titanium tetrachloride catalyst to obtain a compound represented by formula (3), and performing a reaction with paratoluensulfonyl chloride in the presence of an organic solvent and an acid-binding agent to obtain the target compound. The preparation method overcomes the defects of the synthetic method in the prior art, and is suitable for the industrial production. The product has high content, and the purity of the product reaches over 99%.