1398415-57-0Relevant academic research and scientific papers
Ligand-Free Iron-Catalyzed Carbon (sp2)-Carbon (sp2) Oxidative Homo-Coupling of Alkenyllithiums
Zhong, Zhuliang,Wang, Zhi-Yong,Ni, Shao-Fei,Dang, Li,Lee, Hung Kay,Peng, Xiao-Shui,Wong, Henry N. C.
, p. 700 - 704 (2019)
A new strategy was developed for the efficient synthesis of di-, tetra-, and hexa-substituted 1,3-butadienes. This one-pot procedure involves lithium-iodine exchange to generate the corresponding vinyllithium intermediates. A subsequent iron-catalyzed ligand-free oxidative homo-coupling eventually led to the formation of 1,3-butadienes in acceptable to excellent isolated yields.
Palladium-catalyzed alkyne insertion/Suzuki reaction of alkyl iodides
Monks, Brendan M.,Cook, Silas P.
supporting information, p. 15297 - 15300 (2012/11/06)
A palladium-catalyzed alkyne insertion/Suzuki reaction with unactivated alkyl iodides is described. Under the reaction conditions, selective migratory insertion of alkynes avoids β-hydride elimination and provides a facile synthesis of stereodefined, tetrasubstituted olefins. The transformation offers broad substrate scope for both the alkyl iodide and boron nucleophile. Mechanistic studies have revealed inversion of the stereocenter for the carbon bearing the iodide.
