1450719-47-7Relevant academic research and scientific papers
Synthesis of Exocyclic Trisubstituted Alkenes via Nickel- Catalyzed Kumada-Type Cross-Coupling Reaction of gem- Difluoroalkenes with Di-Grignard Reagents
Dai, Wenpeng,Zhang, Xuxue,Zhang, Juan,Lin, Yingyin,Cao, Song
supporting information, p. 183 - 187 (2016/02/16)
A practical, nickel-catalyzed Kumada-type double cross-coupling reaction of gem-difluoroalkenes with 1,4- or 1,5-di-Grignard reagents was developed. The reaction proceeded efficiently at room temperature and a variety of cyclization products, arylmethylenecyclopentanes and arylmethylenecyclohexanes, were obtained in high to excellent yields, respectively.
Palladium-catalyzed alkyne insertion/reduction route to trisubstituted olefins
Fruchey, Erin R.,Monks, Brendan M.,Patterson, Andrea M.,Cook, Silas P.
supporting information, p. 4362 - 4365 (2013/09/24)
A new route to trisubstituted olefins through a palladium-catalyzed alkyne insertion/reduction reaction with unactivated alkyl iodides is reported. The reaction proceeds under mild conditions and tolerates a range of functional groups and substitution patterns. Preliminary mechanistic inquiry suggests that the transformation may proceed through a hybrid radical/organometallic pathway.
