1398508-07-0Relevant academic research and scientific papers
Stereoselective conjugate addition of ketones to alkylidene malonates using thiourea-sulfonamide organocatalyst
Kawada, Masahiro,Nakashima, Kosuke,Hirashima, Shin-ichi,Sakagami, Toru,Koseki, Yuji,Miura, Tsuyoshi
, p. 1215 - 1224 (2018/09/25)
In this study, stereoselective conjugate addition of ketones to alkylidene malonates using organocatalyst has been developed. The reaction in the presence of 20?mol% of a novel thiourea-sulfonamide organocatalyst afforded conjugate adducts in moderate to
Asymmetric michael addition of ketones to alkylidene malonates and allylidene malonates via enamine - Metal lewis acid bifunctional catalysis
Liu, Lu,Sarkisian, Ryan,Xu, Zhenghu,Wang, Hong
supporting information, p. 7693 - 7699 (2012/11/07)
Novel enamine-metal Lewis acid bifunctional catalysts were successfully applied to the asymmetric Michael addition of ketones to alkylidene malonates, offering excellent stereoselectivity (up to >99% ee and >99:1 dr). The asymmetric Michael addition of ketones to allylidene malonates was also achieved.
Highly enantioselective michael addition of ketone to alkylidene malonates catalyzed by binaphthyl sulfonimides in water
Jia, Shengjian,Luo, Chunhua,Du, Daming
, p. 2676 - 2680 (2013/01/15)
Binaphthyl sulfonimides have been developed to catalyze the asymmetric Michael addition of ketone to alkylidene malonates, affording the corresponding Michael products in good to high yields (up to 98%) with good to excellent diastereoselectivity (up to 9
Enantioselective organocatalytic Michael Addition of ketones to alkylidene malonates
Syu, Siang-En,Huang, Chan-Hui,Chen, Ko-Wei,Lee, Chia-Jui,Das, Utpal,Jang, Yeong-Jiunn,Lin, Wenwei
experimental part, p. 600 - 605 (2012/10/07)
Organocatalysts bearing sulfide or sulfone functions () were studied for the direct asymmetric Michael addition of ketones and alkylidene malonates. The organocatalyst (S)-2-((naphthalen-2-ylthio)methyl)pyrrolidine, bearing a pyrrolidine and a sulfide moi
Highly enantioselective conjugate addition of ketones to alkylidene malonates catalyzed by a pyrrolidinyl-camphor-derived organocatalyst
Magar, Dhananjay R.,Chang, Chihliang,Ting, Ying-Fang,Chen, Kwunmin
supporting information; experimental part, p. 2062 - 2066 (2010/06/15)
Pyrrolidinyl-camphor derivatives have been proven to be efficient organocatalysts for enantioselective conjugate addition of ketones to alkylidene malonates, affording high chemical yields (up to 95 %) of the corresponding products with high to excellent levels of diastereoselectivity (up to >99:1 dr) and enantioselectivity (up to 96%ee) under solvent-free reaction conditions at ambient temperature.
