1398565-77-9

Basic information

• Product Name: 2-(3-chlorobenzoyl)-4-(3-chlorophenyl)-4-oxobutanenitrile
• Synonyms: 2-(3-chlorobenzoyl)-4-(3-chlorophenyl)-4-oxobutanenitrile
• CAS NO: 1398565-77-9
• Molecular Weight: 332.186
• Mol File: 1398565-77-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(3-chlorobenzoyl)-4-(3-chlorophenyl)-4-oxobutanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-chlorobenzoyl)-4-(3-chlorophenyl)-4-oxobutanenitrile(1398565-77-9)
• EPA Substance Registry System: 2-(3-chlorobenzoyl)-4-(3-chlorophenyl)-4-oxobutanenitrile(1398565-77-9)

Safety Data

• Hazardous Substances Data: 1398565-77-9(Hazardous Substances Data)

Upstream product

• 35190-07-9 1,2-bis(3-chlorophenyl)ethane-1,2-dione 
• 107-13-1 acrylonitrile 

Relevant articles and documents

N-heterocyclic carbene-catalyzed annulation of α-cyano-1,4-diketones with ynals

In this paper, the first stereoselective annulation reaction between r-cyano-1,4-diketones and ynals, mediated by catalytic amounts of a triazolium salt precatalyst and cocatalytic amounts of a weak carboxylate base, is disclosed. The title transformation proceeds smoothly under mild reaction conditions and generates three contiguous stereogenic centers, one of which is a quaternary acetal carbon. This reaction tolerates a wide variety of electronically distinct substituents on both reaction partners and affords privileged bicyclic scaffolds in 61-90% isolated yields and with up to 20:1 diastereomeric preference.