35190-07-9

Upstream product

• 35190-17-1 3,3'-dichloro-benzoin 
• 587-04-2 m-Chlorobenzaldehyde 
• 92133-96-5 (1H-benzo[d][1,2,3]triazol-1-yl)(3-chlorophenyl)methanone 
• 618-46-2 m-Chlorobenzoyl chloride 
• 37580-83-9 1,2-bis(3-chlorophenyl)-1,2-ethanediol 
• 119488-20-9 1,2-bis-(3-chloro-phenyl)-ethanone 
• 108-37-2 1-bromo-3-chlorobenzene 
• 99-02-5 3'-Chloroacetophenone 
• 5216-30-8 1,2-bis(3-chlorophenyl)ethyne 
• 3240-26-4 1,2-bis(3-chlorophenyl)ethylene 

Downstream Products

• 119488-20-9 1,2-bis-(3-chloro-phenyl)-ethanone 
• 37580-83-9 1,2-bis(3-chlorophenyl)-1,2-ethanediol 
• 85259-23-0 3,3'-dichlorobenzilic acid 
• 111299-18-4 (3-Chloro-phenyl)-[2-(3-chloro-phenyl)-oxiranyl]-methanone 
• 25379-20-8 2-phenylindolizine 
• 101685-42-1 2,3-Bis-(3-chloro-phenyl)-quinolizinylium; bromide 
• 118816-34-5 4-[4,5-Bis-(3-chloro-phenyl)-3-(1-methyl-1H-pyridin-4-ylidene)-cyclopenta-1,4-dienyl]-1-methyl-pyridinium; iodide 
• 93257-89-7 5,5'-Dichlor-2,2'-dinitro-benzil 
• 92030-43-8 3,5'-Dichlor-2,2'-dinitro-benzil 
• 38268-28-9 2,5-Bis-(4-bromo-phenyl)-3,4-bis-(3-chloro-phenyl)-cyclopenta-2,4-dienone 
• 38268-13-2 3,4-Bis-(3-chloro-phenyl)-2,5-diphenyl-cyclopenta-2,4-dienone 
• 4101-01-3 1,2-bis(3-chlorophenyl)-1,1,2,2-tetrafluoroethane 
• 1398565-77-9 2-(3-chlorobenzoyl)-4-(3-chlorophenyl)-4-oxobutanenitrile 
• 37580-83-9 meso-1,2-di(m-chlorophenyl)-1,2-ethanediol 

Relevant academic research and scientific papers

Isostructurality of quinoxaline crystal phases: The interplay of weak hydrogen bonds and halogen bonding

Tailoring the physical properties of molecular crystals though the construction of solid solutions requires the existence of isostructural crystals. Simple substitutions of a given molecular framework can give a range of different crystal structures. A se

Catalyst-Free and Transition-Metal-Free Approach to 1,2-Diketones via Aerobic Alkyne Oxidation

A catalyst-free and transition-metal-free method for the synthesis of 1,2-diketones from aerobic alkyne oxidation was reported. The oxidation of various internal alkynes, especially more challenging aryl-alkyl acetylenes, proceeded smoothly with inexpensive, easily handled, and commercially available potassium persulfate and an ambient air balloon, achieving the corresponding 1,2-diketones with up to 85% yields. Meanwhile, mechanistic studies indicated a radical process, and the two oxygen atoms in the 1,2-diketons were most likely from persulfate salts and molecular oxygen, respectively, rather than water.

Ruthenium/dendrimer complex immobilized on silica-functionalized magnetite nanoparticles catalyzed oxidation of stilbenes to benzil derivatives at room temperature

A new ruthenium/dendrimer complex stabilized on the surface of silica-functionalized nano-magnetite was fabricated and well characterized. The nano-catalyst showed good activity in the synthesis of benzil derivatives via the oxidation of stilbenes with high turnover frequency (TOF) at room temperature. Moreover, the catalyst could also be reused up to fifteen times without any loss of its activity.

Unravelling mechanistic features of organocatalysis with in situ modifications at the secondary sphere

Secondary-sphere interactions serve a fundamental role in controlling the reactivity and selectivity of organometallic and enzymatic catalysts. However, there is a dearth of studies that explicitly incorporate secondary-sphere modifiers into organocatalytic systems. In this work, we introduce an approach for the in situ systematic modification of organocatalysts in their secondary sphere through dynamic covalent binding under the reaction conditions. As a proof-of-concept, we applied boronic acids as secondary-sphere modifiers of N-heterocyclic carbenes that contained a hydroxy handle. The bound system formed in the reaction mixture catalysed the enantioselective benzoin condensations of a challenging substrate class that contains electron-withdrawing groups. Linear regression coupled with data visualization served to pinpoint the divergent origins of enantioselectivity for different substrates and decision tree algorithms served to formulate selection criteria for the appropriate secondary-sphere modifiers. The combination of this highly modular catalytic approach with machine-learning techniques provided mechanistic insights and guided the streamlined optimization process of a gram-scale reaction at low organocatalyst loading.

Substituent Effect in the Synthesis of α,α-Dibromoketones, 1,2-Dibromalkenes, and 1,2-Diketones from the Reaction of Alkynes and Dibromoisocyanuric Acid

Internal alkynes reacted with dibromoisocyanuric acid/H2O to afford α,α-dibromoketone and 1,2-diketone derivatives. Diarylalkynes with activating groups provided 1,2-diketone derivatives as the major products, whereas diarylalkynes with a non-activating group or alkylarylalkynes gave α,α-dibromoketone derivatives as the major products. In addition, diarylalkynes with deactivating groups provided 1,2-dibromoalkenes. The reaction was conducted at room temperature and showed good yields in most cases. Reaction pathways have been proposed on the basis of experimental observations and density functional theory (DFT) calculations. (Figure presented.).

NaBrO3/bmim[HSO4]: a versatile system for the selective oxidation of 1,2-diols, α-hydroxyketones, and alcohols

Abstract: Sodium bromate with bmim[HSO4] has been found to be an excellent oxidizing agent in aqueous medium. NaBrO3:bmim[HSO4] oxidized 1,2-diols, α-hydroxyketones, and alcohols to the corresponding carbonyl compounds in excellent yields. This method offers advantages such as low cost reagents, aqueous reaction conditions, moderate temperatures and short reaction times and hence environmentally benign reaction. Moreover, the ionic liquid bmim[HSO4] could be recycled for at least three times without loss of significant activity. Graphical abstract: [Figure not available: see fulltext.]

Preparing method of photocatalytic alpha-diketone compound

The invention belongs to the technical field of medical and chemical intermediates and related chemicals, and provides a preparing method of photocatalytic alpha-diketone compound. Phenylacetylene and the derivative thereof are used as raw materials, and under the lighting condition, under the combined action of a semiconductor photocatalyst and an additive, alpha-diketone compound is generated through air oxygen in organic solvent. The preparing method has the advantages of being easy to operate, mild in condition and environmentally friendly, has probability of industrialization and obtains the alpha-diketone compound at the high yield, and the catalyst is recyclable. The alpha-diketone compound synthesized through the method can be further functionalized to obtain various compounds applied to development and research of natural products, function materials and fine chemicals.

Chiral Frustrated Lewis Pairs Catalyzed Highly Enantioselective Hydrosilylations of 1,2-Dicarbonyl Compounds

A highly enantioselective hydrosilylation of 1,2-dicarbonyl compounds was successfully realized for the first time utilizing the combination of tricyclohexylphosphine and chiral alkenylborane derived in situ from diyne as a frustrated Lewis pair catalyst. A variety of optically active α-hydroxy ketones and esters were obtained in 52-98% yields with 86-99% ee's.

Lanthanum triflate-catalyzed rapid oxidation of secondary alcohols using hydrogen peroxide urea adduct (UHP) in ionic liquid

A convenient and efficient protocol for the oxidation of secondary hydroxyl group to ketone using hydrogen peroxide-urea adduct and catalytic (CF 3SO3)3La in ionic liquid has been developed. A number of 1,2-diols, -hydroxyketones, and other aromatic and aliphatic secondary alcohols have been successfully oxidized to the corresponding ketones using this protocol in good yields and short reaction times. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]

Synthesis of ferrocene derivatives with planar chirality via palladium-catalyzed enantioselective C-H bond activation

The first catalytic and enantioselective C-H direct acylation of ferrocene derivatives has been developed. A series of 2-acyl-1-dimethylaminomethylferrocenes with planar chirality were provided under highly efficient and concise one-pot conditions with up to 85% yield and 98% ee. The products obtained could be easily converted to various chiral ligands via diverse transformations.