1398653-73-0Relevant academic research and scientific papers
Enantioselective gold catalysis: Opportunities provided by monodentate phosphoramidite ligands with an acyclic TADDOL backbone
Teller, Henrik,Fluegge, Susanne,Goddard, Richard,Fuerstner, Alois
, p. 1949 - 1953 (2010)
(Chemical Equation Presented) The tail makes the difference: Removing the isopropylidene acetal unit from well-known TADDOL ligands improved the performance of the derived phosphoramidite ligands in asymmetric gold catalysis (see scheme; Ts=4-toluenesulfonyl). X-ray crystallography showed that the binding pocket has an effective three-fold symmetry, with through-space interactions between the arene rings of the ligand and the gold center.
