Enantioselective gold catalysis: Opportunities provided by monodentate phosphoramidite ligands with an acyclic TADDOL backbone

DOI: 10.1002/anie.200906550

Source and publish data:

Angewandte Chemie - International Edition p. 1949 - 1953 (2010)

Update date:2022-08-04

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Authors:

Teller, Henrik

Fluegge, Susanne

Goddard, Richard

Fuerstner, Alois

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Article abstract of DOI:10.1002/anie.200906550

(Chemical Equation Presented) The tail makes the difference: Removing the isopropylidene acetal unit from well-known TADDOL ligands improved the performance of the derived phosphoramidite ligands in asymmetric gold catalysis (see scheme; Ts=4-toluenesulfonyl). X-ray crystallography showed that the binding pocket has an effective three-fold symmetry, with through-space interactions between the arene rings of the ligand and the gold center.

Full text of DOI:10.1002/anie.200906550

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