1398700-79-2Relevant academic research and scientific papers
Copper(I)-catalyzed decarboxylative coupling of propiolic acids with secondary amines and aldehydes
Ermolat'ev, Denis S.,Feng, Huangdi,Song, Gonghua,Van Der Eycken, Erik V.
supporting information, p. 5346 - 5350 (2014/09/30)
An efficient microwave-assisted synthesis of tertiary propargylamines has been developed by copper(I)-catalyzed decarboxylative A3-coupling reaction of an alkynylcarboxylic acid with a secondary amine and an aldehyde. A wide range of diversely substituted propargylamines could be synthesized in high yields. The optimal reaction conditions are also effective for 3-alkylpropiolic acids and for terminal propiolic acid. Copyright
Copper(I)-catalysed deacetylenative cross-coupling reaction of terminal alkynes with propargylic amines via C(sp)-C(sp3) bond cleavage
Kim, Yongeun,Nakamura, Hiroyuki
, p. 1686 - 1690 (2012/07/17)
The catalytic deacetylenative coupling reaction of terminal alkynes with various N-substituted propargylic amines proceeded in the presence of CuCl (10 mol%) and NaPO(4 equiv) in THF at 130 °C to give the corresponding substituted propargylic amines in go
