1398756-64-3Relevant academic research and scientific papers
Fast, cell-compatible click chemistry with copper-chelating azides for biomolecular labeling
Uttamapinant, Chayasith,Tangpeerachaikul, Anupong,Grecian, Scott,Clarke, Scott,Singh, Upinder,Slade, Peter,Gee, Kyle R.,Ting, Alice Y.
, p. 5852 - 5856 (2012)
Bring your own copper: Copper-chelating azides undergo much faster click reactions (CuAAC) than nonchelating azides under a variety of biocompatible conditions. This kinetic enhancement allows site-specific protein labeling to be performed on the surface of living cells with only 10-40μM Cu I/CuII (see scheme). Detection sensitivity was also increased for CuAAC detection of alkyne-modified proteins and RNA. Copyright
