139885-35-1Relevant articles and documents
REACTION OF N-TRIMETHYLSILYLLACTAMS WITH N-SUBSTITUTED DERIVATIVES OF CHLOROACETAMIDE
Zheltonogova, E. A.,Orlova, N. A.,Kobzareva, V. P.,Shipov, A. G.,Baukov, Yu. I.
, p. 2092 - 2099 (2007/10/02)
The reaction of N-silyl-substituted 5-, 6-, and 7-member lactams with primary and secondary chloroacetamides and with 3-chloroacetyl-5-oxazolidinones yields the corresponding products of N-amidomethylation of the lactams.When N-chloroacetyl derivatives of α-amino acid enantiomers are used, the optical activity is preserved in the products of alkylation.It was demonstrated with L-valine derivatives that the configuration of the starting α-amino acid is also preserved.The corresponding amides of peptides with a lactam fragment were obtained when the products of N-alkylation of lactams were treated with primary amines.
