139893-84-8

Upstream product

• 67-56-1 methanol 
• 134235-80-6 (1S,3S,4R) methyl 3,4-epoxy-1-cyclohexanecarboxylate 
• 139893-81-5 (1S,4S,5S)-4-bromo-6-oxabicyclo<3.2.1>octan-7-one 
• 139893-82-6 (1S,3S,4S) methyl 4-bromo-3-hydroxy-1-cyclohexenecarboxylate 
• 5708-19-0 (1S)-3-cyclohexenecarboxylic acid 

Relevant academic research and scientific papers

NITROOXY CYCLOALKANE DERIVATIVES

A compound having the structure wherein Y is selected from the group consisting of –C(O)OR2, -C(O)NHR8, -C(CH2)1-2OR3, OH, and or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension.

Practical, asymmetric synthesis of the cyclohexyl C28-C34 fragment of the immunosuppressant FK-506 via (S)-(-)-3-cyclohexenecarboxylic acid

The asymmetric synthesis of the cyclohexyl fragment of FK-506 is reported. This new synthesis (five steps, 30% overall yield) starts, for the first time, from (S)-(-)-3-cyclohexenecarboxylic acid (S-2) instead of the commonly used R form (acid R-2) and utilizes an epimerization reaction. The overall yield is improved to 35% by recycling recovered starting product (hydroxy ester 7c) from the epimerization step.