1399086-36-2

Upstream product

• 551-93-9 2-aminoacetophenone 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 144221-09-0 (E)-1-(2'-aminophenyl)-3-(4-bromophenyl)-2-propen-1-one 

Downstream Products

• 1399086-23-7 (R)-(E)-4-(4-(4-bromostyryl)-3-formyl-4-hydroxy-1-(trifluoromethylsulfonyl)-1,4-dihydroquinolin-2-yl)benzonitrile 
• 1399086-21-5 (R)-(E)-4-(4-bromostyryl)-4-hydroxy-2-(3-nitrophenyl)-1-(trifluoromethylsulfonyl)-1,4-dihydroquinoline-3-carbaldehyde 
• 1399086-20-4 (R)-(E)-4-(4-bromostyryl)-4-hydroxy-2-phenyl-1-(trifluoromethylsulfonyl)-1,4-dihydroquinoline-3-carbaldehyde 

Relevant academic research and scientific papers

An organocatalytic cascade approach toward polysubstituted quinolines and chiral 1,4-dihydroquinolines-unanticipated effect of N-protecting groups

A matter of protection: The outcome of a divergent organocatalytic aza-Michael/aldol cascade process toward quinolines and 1,4-dihydroquinolines depends on the choice of the N-protecting group (see scheme; TEA=triethylamine, TMS=trimethylsilyl). Use of an electron-donating sulfonyl group results in an unanticipated aza-Michael/aldol/aromatization cascade to give polysubstituted quinolines (right). In contrast, chiral 1,4-dihydroquinolines are obtained with an electron-withdrawing sulfonyl group (left). Copyright