139926-24-2Relevant academic research and scientific papers
5-HETEROCYCLYL PYRAZOLO 4,3-D]PYRIMIDIN-7-ONES FOR THE TREATMENT OF MALE ERECTILE DYSFUNCTION
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Page 13, (2008/06/13)
The invention is directed to novel substituted 5-heterocyclyl pyrazolopyrimidinones and derivatives thereof, their synthesis and their use in treating sexual dysfunction in mammals, especially male erectile dysfunction. Pharmaceutical compositions containing the compounds and methods of using them to treat sexual dysfunction are also described.
Synthesis and properties of α-thiagra. A substituted 5-(2-thienyl)pyrazolo[4,3-d]pyrimidin-7-one bioisostere of viagra
El-Abadelah, Mustafa M.,Sabri, Salim S.,Khanfar, Monther A.,Voelter, Wolfgang,Abdel-Jalil, Raid J.,Maichle-Moessmer, Caecilia,Al-Abed, Yousef
, p. 2643 - 2652 (2007/10/03)
For structure-activity manipulations, the compound α-thiagra (3), a thiophene bioisostere of viagra, has been prepared and its X-Ray structure determined. The crystallographic data show that the thiophene and pyrazolo[4,3-d]pyrimidone hetero-ring systems are nearly coplanar by virtue of an adequate intramolecular hydrogen-bond between the pyrimidone NH and the oxygen lone pair of the 3'-ethoxy group.
Synthesis and preliminary pharmacological study of thiophene analogues of the antipyretic and analgesic agent ethenzamide
Darias,Bravo,Abdallah,Sanchez Mateo,Exposito-Orta
, p. 83 - 87 (2007/10/02)
A preliminary pharmacologcal study of a thiophene analogue 1b of the analgesic and antipyretic agent Ethenzamide and of a closely related compound 1a showed that a great similarity exists among Ethenzamide and the thiophenic compounds for analgesic, antipyretic, ulcerogenic, hypothermic, and sedative effects. However, the acute toxicity in mice for the thiophenic compounds is notably higher than that of Ethenzamide.
