139927-19-8

Basic information

• Product Name: 2-Azabicyclo[2.2.1]hept-5-ene-3-carboxylicacid,ethylester(9CI)
• Synonyms: 2-Azabicyclo[2.2.1]hept-5-ene-3-carboxylicacid,ethylester(9CI);2-Azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid ethyl ester
• CAS NO: 139927-19-8
• Molecular Formula: C₉H₁₃NO₂
• Molecular Weight: 0
• Product Categories: PYRROLE
• Mol File: 139927-19-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Azabicyclo[2.2.1]hept-5-ene-3-carboxylicacid,ethylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Azabicyclo[2.2.1]hept-5-ene-3-carboxylicacid,ethylester(9CI)(139927-19-8)
• EPA Substance Registry System: 2-Azabicyclo[2.2.1]hept-5-ene-3-carboxylicacid,ethylester(9CI)(139927-19-8)

Safety Data

• Hazardous Substances Data: 139927-19-8(Hazardous Substances Data)

Usage

Chemical compound

2-Azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid, ethyl ester (9CI)
Derivative of a bicyclic compound
Contains a carboxylic acid group
Used in organic synthesis and pharmaceutical research
Building block for various derivatives and analogs
Exhibits biological activity
Potential candidate for pharmaceutical development
Easier handling and manipulation in laboratory settings due to its ethyl ester form
Diverse range of applications in chemical and pharmaceutical industries.

Upstream product

• 924-44-7 glyoxylic acid ethyl ester 
• 542-92-7 cyclopenta-1,3-diene 

Downstream Products

• 139927-10-9 Sodium; (1R,3S,4S)-2-benzoyl-2-aza-bicyclo[2.2.1]hept-5-ene-3-carboxylate 
• 139927-10-9 Sodium; (1S,3S,4R)-2-benzoyl-2-aza-bicyclo[2.2.1]hept-5-ene-3-carboxylate 
• 139927-12-1 4-endo-benzoylamino-2-oxabicyclo[3.3.0]oct-7-en-3-one 
• 139927-12-1 4-exo-benzoylamino-2-oxabicyclo<3.3.0>oct-7-en-3-one 
• 139927-11-0 2-(p-nitrobenzoyl)-2-azabicyclo<2.2.1>hept-5-ene-3-endo-carboxylic acid 
• 139952-80-0 ethyl 2-(p-nitrobenzoyl)-2-azabicyclo<2.2.1>hept-5-ene-3-endo-carboxylate 
• 139927-09-6 ethyl 2-benzoyl-2-azabicyclo<2.2.1>hept-5-ene-3-exo-carboxylate 
• 139927-09-6 ethyl 2-benzoyl-2-azabicyclo<2.2.1>hept-5-ene-3-endo-carboxylate 

Relevant articles and documents

SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS

The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

Reactions of ethyl 2-acetyl-2-azabicyclohept-5-ene-3-carboxylate and 4-acetylamino-2-oxabicyclooct-7-en-3-one with some electrophiles

The amide 3 reacted with various electrophilic reagents to give the addition products 5-9; reaction of 3 with m-chloroperoxybenzoic acid (MCPBA) gave the epoxide 10; similarly, the lactone 4 (an isomer of 3) reacted extremely selectively with a variety of electrophiles to give a range of polyfunctionalised bicyclic systems 12-15: reaction with MCPBA gave the epoxide 16 as the major product.