13993-24-3Relevant academic research and scientific papers
1-PIPERAZINES AND SOME RELATED COMPOUNDS
Valenta, Vladimir,Bartosova, Marie,Protiva, Miroslav
, p. 1280 - 1287 (2007/10/02)
Amino alcohols VIIIa-c, prepared by reduction of the Mannich bases VIa-c, were transformed by treatment with thionyl chloride to the chloro derivatives IXa-c which were subjected to substituttion reactions with the sodium salts of guaiacol, 2-ethoxyphenol and 2-benzyloxyphenol giving the title compounds IIIb,c, IVb,c and Va-c.N,N-Dimethyl-3-(2-benzyloxyphenoxy)-3-phenylpropylamine (Va) was partially demethylated by treatment with ethyl chloroformate and by the following alkaline hydrolysis to the secondary amine XI.Amines III-V and XI in high doses exhibit centralexcitation but do not show antireserpine activity; they have several structurally less specific effects (hypotensive, local anaesthetic, spasmolytic).
