1399679-99-2

Upstream product

• 118207-36-6 (2R,3S)-1,2-epoxy-3-<(4-methoxybenzyl)oxy>pent-4-ene 
• 1399680-27-3 (3R,6R,7S)-(3S,4S,E)-3,5-dimethyl-7-(trityloxy)hepta-1,5-dien-4-yl 3-((tert-butyldimethylsilyl)oxy)-7-((4-methoxybenzyl)oxy)-6-methyl-6-((triethylsilyl)oxy)non-8-enoate 
• 1399679-69-6 (3S,4S,E)-3,5-dimethyl-7-(trityloxy)hepta-1,5-dien-4-ol 
• 1399679-95-8 (E)-2-methyl-4-(trityloxy)but-2-enal 
• 1399679-90-3 (E)-2-methyl-4-(trityloxy)but-2-en-1-ol 
• 141561-63-9 (((3-methylbut-2-en-1-yl)oxy)methanetrityl)tribenzene 
• 556-82-1 3-methyl-2-buten-1-ol 
• 1399679-73-2 (3R,6R,7S)-3-((tert-butyldimethylsilyl)oxy)-7-((4-methoxybenzyl)oxy)-6-methyl-6-((triethylsilyl)oxy)non-8-enoic acid 
• 1399679-86-7 (3R,6R,7S)-tert-butyl 3-((tert-butyldimethylsilyl)oxy)-6-hydroxy-7-((4-methoxybenzyl)oxy)-6-methylnon-8-enoate 
• 1399680-24-0 (3R,7S)-tert-butyl 3-((tert-butyldimethylsilyl)oxy)-7-((4-methoxybenzyl)oxy)-6-oxonon-8-enoate 
• 1399679-83-4 (3R,6R,7S)-tert-butyl 3-((tert-butyldimethylsilyl)oxy)-7-((4-methoxybenzyl)oxy)-6-((triethylsilyl)oxy)non-8-enoate 
• 1399680-21-7 (3R,6R,7S)-tert-butyl 3-hydroxy-7-((4-methoxybenzyl)oxy)-6-((triethylsilyl)oxy)non-8-enoate 
• 922-65-6 divinylcarbinol 
• 1399679-81-2 (6R,7S)-tert-butyl 7-((4-methoxybenzyl)oxy)-3-oxo-6-((triethylsilyl)oxy)non-8-enoate 

Downstream Products

• 1399680-44-4 (4R,7R,8S,11R,12R,E)-4-((tert-butyldimethylsilyl)oxy)-8-hydroxy-7,11-dimethyl-7-((triethylsilyl)oxy)-12-((E)-4-(trityloxy)but-2-en-2-yl)oxacyclododec-9-en-2-one 
• 1399680-29-5 (E)-4-((tert-butyldimethylsilyl)oxy)-8-hydroxy-7,11-dimethyl-7-((triethylsilyl)oxy)-12-((E)-4-(trityloxy)but-2-en-2-yl)oxacyclododec-9-en-2-one 
• 1399680-03-5 (E)-10-((tert-butyldimethylsilyl)oxy)-3,7-dimethyl-12-oxo-7-((triethylsilyl)oxy)-2-((E)-4-(trityloxy)but-2-en-2-yl)oxacyclododec-4-en-6-yl acetate 
• 445493-23-2 (2S,3S,6S,7R,10R,E)-7,10-dihydroxy-2-{(S,2E,4E)-7-[(2R,3R)-3-{(2R,3S)-3-hydroxypentan-2-yl}oxiran-2-yl]-6-methylhepta-2,4-dien-2-yl}-3,7-dimethyl-12-oxooxacyclododec-4-en-6-yl acetate 

Relevant academic research and scientific papers

Enantioselective total synthesis of pladienolide B: A potent spliceosome inhibitor

An enantioselective and convergent total synthesis of pladienolide B (1) is described. Pladienolide B binds to the SF3b complex of a spliceosome and inhibits mRNA splicing activity. The synthesis features an epoxide opening reaction, an asymmetric reduction of a β-keto ester, and a cross metathesis strategy for the side chain synthesis.