1399841-11-2Relevant articles and documents
Catalytic dynamic kinetic resolutions with N-heterocyclic carbenes: Asymmetric synthesis of highly substituted β-lactones
Cohen, Daniel T.,Eichman, Chad C.,Phillips, Eric M.,Zarefsky, Emily R.,Scheidt, Karl A.
, p. 7309 - 7313 (2012/08/28)
New DKR type: An N-heterocyclic carbene (NHC)-catalyzed dynamic kinetic resolution of racemic α-substituted β-keto esters has been developed. This method relies on the epimerization of an NHC-enol intermediate before subsequent aldol/acylation events. Hig