57477-98-2

Basic information

• Product Name: 3-BIPHENYL-4-YL-3-OXO-PROPIONIC ACID ETHYL ESTER
• Synonyms: ETHYL (4-PHENYLBENZOYL)ACETATE;ETHYL 3-(4-BIPHENYL)-3-OXOPROPANOATE;3-BIPHENYL-4-YL-3-OXO-PROPIONIC ACID ETHYL ESTER;EETHYL 3-(BIPHENYL-4-YL)-3-OXOPROPANOATE;ethyl 3-(biphenyl-4-yl)-3-oxopropanoate;b-Oxo-biphenyl-4-propanoic acid ethyl ester
• CAS NO: 57477-98-2
• Molecular Formula: C₁₇H₁₆O₃
• Molecular Weight: 268.31
• Mol File: 57477-98-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 99-102 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 391.8 °C at 760 mmHg
• Flash Point: 172.2 °C
• Appearance: /
• Density: 1.121 g/cm³
• Vapor Pressure: 2.41E-06mmHg at 25°C
• Refractive Index: 1.552
• PKA: 9.85±0.25(Predicted)
• CAS DataBase Reference: 3-BIPHENYL-4-YL-3-OXO-PROPIONIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BIPHENYL-4-YL-3-OXO-PROPIONIC ACID ETHYL ESTER(57477-98-2)
• EPA Substance Registry System: 3-BIPHENYL-4-YL-3-OXO-PROPIONIC ACID ETHYL ESTER(57477-98-2)

Safety Data

• Hazardous Substances Data: 57477-98-2(Hazardous Substances Data)

Usage

General Description

3-Biphenyl-4-yl-3-oxo-propionic acid ethyl ester is a chemical compound belonging to the ester group, which are often used in a variety of applications including the production of plastics, resins, and pharmaceuticals. Featuring three prominent sectors: a biphenyl group, an oxo group, and an ethyl ester group, it is characterized by a structural arrangement that includes carbon, hydrogen, and oxygen atoms. As of now, there is limited publicly available information about this chemical including its common uses, hazards, or safety measures. Researchers or industry professionals who handle such chemicals are typically equipped with specific knowledge about their properties and potential risks.

InChI:InChI=1/C17H16O3/c1-2-20-17(19)12-16(18)15-10-8-14(9-11-15)13-6-4-3-5-7-13/h3-11H,2,12H2,1H3

Upstream product

• 15226-74-1 dicobalt octacarbonyl 
• 1591-31-7 4-iodo-biphenyl 
• 6148-64-7 ethyl potassium malonate 
• 92-66-0 4-bromo-1,1'-biphenyl 
• 17763-78-9 4-phenylphenyl triflate 
• 82102-37-2 9-methyl-9H-fluorene-9-carbonyl chloride 
• 92-91-1 biphenyl-4-acetaldehyde 
• 105-58-8 Diethyl carbonate 
• 1071-46-1 hydrogen ethyl malonate 
• 14002-51-8 4-biphenyl-carboxylic acid chloride 

Downstream Products

• 7377-48-2 2-Amino-6-biphenyl-4-yl-3H-pyrimidin-4-one 
• 690958-93-1 ethyl di(biphenyl-4-carbonyl) acetate 
• 59852-14-1 5-biphenyl-4-yl-5-methyl-pyrazolidin-3-one 
• 260968-52-3 6-(biphenyl-4-yl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one 
• 1314116-77-2 2-(4'-biphenylcarbonyl)-1,2-dihydrobenzo[f]chromen-3-one 
• 1314116-90-9 6-(biphenyl-4-yl)-5-[(2-hydroxynaphthalen-1-yl)methyl]-2-thioxo-2,3-dihydropyrimidin-4(1H)-one 
• 1314117-01-5 C₂₆H₁₆O₃ 
• 1399841-11-2 (1S,4R,5S)-ethyl 5-([1,1'-biphenyl]-4-yl)-7-oxo-6-oxabicyclo[3.2.0]heptane-4-carboxylate 

Relevant articles and documents

Electrochemical Oxidative Cyclization: Synthesis of Polysubstituted Pyrrole from Enamines

A conceptually novel method for the preparation of pyrrole is described by electrochemical-oxidation-induced intermolecular annulation via enamines. In a simple undivided cell, based on a sodium acetate-facilitated, polysubstituted pyrrole derivations has been facilely synthesized under external oxidant-free condition. This electrosynthetic approach providing an environmentally benign protocol for C?C bond cross-coupling and oxidative annulation, which features unparalleled broad scope of substrates and practicality.

Radical Aza-Cyclization of α-Imino-oxy Acids for Synthesis of Alkene-Containing N-Heterocycles via Dual Cobaloxime and Photoredox Catalysis

Nitrogen-containing heterocycles are prevalent in both naturally and synthetically bioactive molecules. We report herein an unprecedented protocol for radical aza-cyclization of α-imino-oxy acids with pendant alkenes via synergistic photoredox and cobaloxime catalysis. With or without alkenes as the intermolecular cross-coupling partners, the transformation provides a variety of corresponding alkene-containing dihydropyrrole products in satisfactory yields. In the presence of external alkenes, the tandem reaction generates E-selective coupling products with excellent chemo- and stereoselectivity.

Access to β-keto esters by palladium-catalyzed carbonylative coupling of aryl halides with monoester potassium malonates

New tricks for an old dog: The Pd-catalyzed carbonylative α-arylation of monoethyl potassium malonates with aryl bromides and reactive aryl chlorides provides a simple and direct route to aryl β-ketoesters. Because only stoichiometric amounts of carbon monoxide are employed, the method is ideal for the introduction of carbon isotopes into more complex structures. Copyright