1399859-50-7Relevant articles and documents
Stereoselective synthesis of enantiopure N-protected-3-arylpiperazines from keto-esters
Jida, Mouhamad,Laconde, Guillaume,Soueidan, Olivier-Mohamad,Lebegue, Nicolas,Revelant, Germain,Pelinski, Lydie,Agbossou-Niedercorn, Francine,Deprez, Benoit,Deprez-Poulain, Rebecca
supporting information, p. 5215 - 5218 (2012/11/07)
An efficient method for a stereoselective synthesis of optically pure N-Boc-3-arylpiperazines has been developed. After optimization of the protecting group strategy and experimental conditions, compounds were obtained via a highly stereoselective synthesis in up to 45% overall yield. This is a practical route to optically pure piperazines for medicinal chemistry.