1399861-03-0 Usage
Uses
Used in Pharmaceutical Industry:
ε-N-crotonyl lysine is used as a potential therapeutic agent for the treatment of various diseases, including cancer and metabolic disorders, due to its involvement in gene expression regulation and its role in biological processes such as transcriptional regulation, DNA repair, and cell differentiation.
Used in Diagnostic Applications:
ε-N-crotonyl lysine is used as a potential biomarker for the diagnosis of diseases, given its involvement in the regulation of gene expression and its association with various biological processes.
Used in Research and Development:
ε-N-crotonyl lysine is used as a research tool for studying the epigenetic regulatory network and its role in various biological processes, which can contribute to the development of new therapeutic strategies and diagnostic methods.
Check Digit Verification of cas no
The CAS Registry Mumber 1399861-03-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,9,9,8,6 and 1 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1399861-03:
(9*1)+(8*3)+(7*9)+(6*9)+(5*8)+(4*6)+(3*1)+(2*0)+(1*3)=220
220 % 10 = 0
So 1399861-03-0 is a valid CAS Registry Number.
1399861-03-0Relevant academic research and scientific papers
Synthesis of ε-N-propionyl-, ε-N-butyryl-, and ε-N-crotonyl-lysine containing histone H3 using the pyrrolysine system
Gattner, Michael J.,Vrabel, Milan,Carell, Thomas
supporting information, p. 379 - 381 (2013/02/22)
Recently new lysine modifications were detected in histones and other proteins. Using the pyrrolysine amber suppression system we genetically inserted three of the new amino acids ε-N-propionyl-, ε-N-butyryl-, and ε-N-crotonyl-lysine site specifically int
Site-specific incorporation of μ-N-crotonyllysine into histones
Kim, Chan Hyuk,Kang, Mingchao,Kim, Hak Joong,Chatterjee, Abhishek,Schultz, Peter G.
supporting information; experimental part, p. 7246 - 7249 (2012/09/07)
A novel post-translationally modified amino acid, crotonyllysine (Kcr), was genetically incorporated into proteins in bacterial and mammalian cells using an evolved pyrrolysyl-tRNA/synthetase-tRNA pair. The ability to produce histones with homogenous, site-specific Kcr modifications will be valuable in elucidating the biological role of this recently identified post-translational modification. Copyright
