14003-46-4

Basic information

• Product Name: 2-(quinolin-4-yl)acetonitrile
• Synonyms: 2-(quinolin-4-yl)acetonitrile;4-Quinolineacetonitrile;2-(4-quinolyl)acetonitrile
• CAS NO: 14003-46-4
• Molecular Formula: C11H8N2
• Molecular Weight: 168.2
• Mol File: 14003-46-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 355.9°Cat760mmHg
• Flash Point: 123.3°C
• Appearance: /
• Density: 1.176g/cm³
• Vapor Pressure: 3.03E-05mmHg at 25°C
• Refractive Index: 1.642
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(quinolin-4-yl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(quinolin-4-yl)acetonitrile(14003-46-4)
• EPA Substance Registry System: 2-(quinolin-4-yl)acetonitrile(14003-46-4)

Safety Data

• Hazardous Substances Data: 14003-46-4(Hazardous Substances Data)

Usage

Uses

4-Quinolineacetonitrile is an reagent used in the synthetic preparation of potential bone morphogenetic protein (BMP) signaling inhibitor.

InChI:InChI=1/C11H8N2/c12-7-5-9-6-8-13-11-4-2-1-3-10(9)11/h1-4,6,8H,5H2

Upstream product

• 491-35-0 C₆H₄NCH₂CHCCH₂ 
• 18773-77-8 methyl(phenyl)cyanamide 
• 91973-99-8 3-[4]quinolyl-2-hydroxyimino-propionic acid 
• 611-35-8 4-chloroquinoline 
• 18852-51-2 sodium cyanoacetic acid ethyl ester 
• 5632-17-7 4-(chloromethyl)quinoline 
• 6281-32-9 4-quinolylmethanol 
• 13119-77-2 2-oxo-3-quinolin-4-yl-propionic acid ethyl ester 
• 4363-93-3 quinoline-4-carboxaldehyde 
• 2942-58-7 diethyl cyanophosphonate 
• 109558-06-7 benzoyloxy-[4]quinolyl-acetonitrile 

Downstream Products

• 24675-10-3 2-[4]quinolyl-3c-(4-dimethylamino-phenyl)-acrylonitrile 
• 109553-90-4 [4]quinolyl-(4-dimethylamino-phenylimino)-acetonitrile 
• 4789-81-5 ethyl 4-quinolineacetate 
• 1062368-21-1 4-quinolin-4-yl-2H-pyrazol-3-ylamine 
• 1062368-22-2 C₂₁H₁₃BrN₄ 
• 1062368-24-4 LDN-193189 
• 1062368-23-3 C₃₃H₂₈N₆O₂ 
• 1187313-01-4 C₂₆H₂₃N₅ 
• 1187313-00-3 C₂₇H₂₅N₅O 
• 1187313-20-7 C₃₁H₃₁N₅O₂ 
• 1187313-18-3 C₃₁H₂₉N₅O₂ 
• 1187313-23-0 C₃₁H₃₁N₅O₃ 
• 1187313-12-7 C₃₂H₃₃N₅O₃ 

Relevant articles and documents

INHIBITORS OF THE BMP SIGNALING PATHWAY

The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation.

An improved method for direct conversion of heteroaryl-aldehydes to heteroaryl-acetonitriles

Treatment of heteroaryl-aldehydes with diethyl cyanophosphonate in the presence of a catalytic amount of LiCN affords phosphorylated cyanohydrins which are reduced in situ with SmI2 to give heteroaryl-acetonitriles in generally good overall yields (50-100%). The generality of the process is demonstrated.