1400413-82-2

Upstream product

• 52751-67-4 3,5-bis-(4-methoxyphenyl) isoxazole 
• 6783-05-7 trans-2-phenylvinylboronic acid 
• 258860-15-0 4-iodo-3,5-bis(4-methoxyphenyl)isoxazole 
• 18362-51-1 1,3-bis(4'-methoxyphenyl)propane-1,3-dione 

Downstream Products

• 1400414-08-5 (E)-4-styryl-3,5-bis(4-hydroxyphenyl)isoxazole 

Relevant academic research and scientific papers

Synthesis and evaluation of 4-(substituted styryl/alkenyl)-3,5-bis(4- hydroxyphenyl)-isoxazoles as ligands for the estrogen receptor

A series of 3,5-bis (4-hydroxyphenyl) isoxazoles bearing a styryl/alkyl vinyl group at the 4-position were prepared and evaluated as ligands for the estrogen receptor-alpha (ERα). The target compounds were prepared using the Suzuki reaction to couple an iodo-isoxazole intermediate with a series of styryl/alkenyl boronic acids, followed by O-demethylation. The products were evaluated for their estrogen receptor-α ligand binding domain (ERα-LBD) binding affinity using a competitive binding assay. The 4-(4-hydroxystyryl) derivative 4 h displays binding properties similar to those of the previously described pyrazole class of ER ligands, indicating that the ERα-LBD tolerates the presence of the added vinyl group at the 4-position of the isoxazole ring.