14005-51-7Relevant academic research and scientific papers
A simple and efficient approach for the synthesis of 2-aminated quinazoline derivatives via metal free oxidative annulation
Pandya, Amit N.,Villa, Eric M.,North, E. Jeffrey
supporting information, p. 1276 - 1279 (2017/03/10)
A simple and efficient approach for the synthesis of 2-aminoquinazoline derivatives in moderate to good yields. This reaction employs mild reaction conditions, is metal-free and utilizes readily available starting materials making it a more viable reaction for scale up synthesis and ligand diversity. Notably, this methodology allows for the synthesis of 2-aminoquinazolines using a free amine or cyclic amine enabling structural diversity and good atom economy.
Copper(II) acetate/oxygen-mediated nucleophilic addition and intramolecular C-H activation/C-N or C-C bond formation: One-pot synthesis of benzimidazoles or quinazolines
He, Hua-Feng,Wang, Zhi-Jing,Bao, Weiliang
supporting information; experimental part, p. 2905 - 2912 (2010/12/29)
Diarylcarbodiimides or benzylphenylcarbodiimides are converted to 1,2-disubstituted benzimidazoles or 1,2-disustituted quinazolines via addition/intramolecular C-H bond activation/C-N or C-C bond forming reaction using copper(II) acetate/oxygen [Cu(OAc)2/O2] as the oxidant at 100°C in one-pot cascade procedure. Copyright
Efficient copper-catalyzed synthesis of 2-amino-4(3h)-quinazolinone and 2-aminoquinazoline derivatives
Huang, Xuhu,Yang, Haijun,Fu, Hua,Qiao, Renzhong,Zhao, Yufen
experimental part, p. 2679 - 2688 (2010/01/21)
We have developed a versatile and efficient method for copper-catalyzed synthesis of both 2-amino-4(3H)-quinazolinone and 2-aminoquinazoline derivatives. The protocol uses readily available substituted 2-halobenzoic acids, 2-bromobenzaldehyde, 2-bromophen
