1400575-63-4Relevant academic research and scientific papers
Discovery of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel, allosteric mGluR5 antagonists
Koller, Manuel,Carcache, David A.,Orain, David,Ertl, Peter,Behnke, Dirk,Desrayaud, Sandrine,Laue, Grit,Vranesic, Ivo
, p. 6454 - 6459 (2012)
1H-pyrrolo[2,3-c]pyridine-7-carboxamides constitute a new series of allosteric mGluR5 antagonists. Variation of the substituents attached to the heterocyclic scaffold allowed to improve the physico-chemical parameters for optimization of the aqueous solubility while retaining high in vitro potency.
