1400590-28-4

Basic information

• Product Name: 3-(4-acetyl-2-methoxyphenoxy)propyl 4-(6-fluorobenzo[d]isoxazol-3-yl)piperidine-1-carboxylate
• Synonyms: 3-(4-acetyl-2-methoxyphenoxy)propyl 4-(6-fluorobenzo[d]isoxazol-3-yl)piperidine-1-carboxylate
• CAS NO: 1400590-28-4
• Molecular Weight: 470.498
• Mol File: 1400590-28-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(4-acetyl-2-methoxyphenoxy)propyl 4-(6-fluorobenzo[d]isoxazol-3-yl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-acetyl-2-methoxyphenoxy)propyl 4-(6-fluorobenzo[d]isoxazol-3-yl)piperidine-1-carboxylate(1400590-28-4)
• EPA Substance Registry System: 3-(4-acetyl-2-methoxyphenoxy)propyl 4-(6-fluorobenzo[d]isoxazol-3-yl)piperidine-1-carboxylate(1400590-28-4)

Safety Data

• Hazardous Substances Data: 1400590-28-4(Hazardous Substances Data)

Upstream product

• 58113-30-7 4-(3-chloropropoxy)-3-methoxyacetophenone 
• 584-08-7 potassium carbonate 
• 84163-13-3 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 
• 534-17-8 caesium carbonate 
• 84163-77-9 6-fluoro-3-(4-piperidinyl)benzo[d]isoxazole 

Relevant articles and documents

Improved and efficient process for the production of highly pure iloperidone: A psychotropic agent

The present work describes an improved and highly efficient process for the synthesis of iloperidone (1), an antipsychotic agent, which is free from potential impurities. The synthesis comprises N-alkylation of 1-(4-(3-chloropropoxy)-3-methoxyphenyl)ethanone (4) with 6-fluoro-3-piperidin-4- yl-1,2-benzisoxazole hydrochloride (5) in a mixture of water and heptane as solvent and sodium hydroxide as a base in the presence of tetrabutylammonium bromide as a phase transfer catalyst to yield iloperidone (1) with a yield of around 95% and a purity of 99.80% by HPLC. The present work also describes the optimization details performed to achieve the process attributes responsible for high yield and purity.