14006-70-3

Usage

Molecular structure

1-Propanone, 3-(1H-indol-3-yl)-1-(4-methoxyphenyl)is a chemical compound with a complex molecular structure that includes a propanone group, an indol-3-yl group, and a 4-methoxyphenyl group.

Classification

It is an aromatic ketone.

Usage

Commonly used in organic synthesis and pharmaceutical research.

Chemical properties

The presence of the indol-3-yl and 4-methoxyphenyl groups imparts unique chemical properties to 1-Propanone, 3-(1H-indol-3-yl)-1-(4-methoxyphenyl)-.

Biological activities

The presence of the indol-3-yl and 4-methoxyphenyl groups may give 1-Propanone, 3-(1H-indol-3-yl)-1-(4-methoxyphenyl)- potential biological activities.

Applications

It may have applications in the development of new pharmaceuticals or as a starting material for the synthesis of other compounds with specific biological activities.

Research interest

The complex structure of this chemical makes it an interesting target for further research and investigation.

Upstream product

• 120-72-9 indole 
• 7448-86-4 1-(4-methoxyphenyl)prop-2-en-1-one 
• 1416983-93-1 1-(3-hydroperoxyprop-1-ynyl)-4-methoxybenzene 
• 173019-85-7 3-bromo-1-(4-methoxyphenyl)propyne 
• 121-97-1 4-Methoxypropiophenone 

Downstream Products

• 1175675-37-2 2-(4-methoxyphenyl)-9H-pyrido[2,3-b]indole 
• 43216-96-2 3-[3-(4-methoxy-phenyl)-propyl]-indole 

Relevant academic research and scientific papers

Concise Synthesis of Spiro[indoline-3,2′-pyrrolidine] and 1-Azacarbazole Derivatives via Copper-Catalyzed Cyclization of Indoles

A high-yielding, copper-catalyzed dearomatization reaction of indole from 2-methylindole-derived oxime acetates was realized, providing access to structurally novel spiro[indoline-3,2′-pyrrolidine] derivatives in 67–98% yields. When the C-2 position of the indole was not substituted, azacarbazole derivatives were obtained in moderate yields. This transformation provides an efficient approach to access nitrogen-containing spiroindolenine and azacarbazole derivatives with wide substrate scope. (Figure presented.).

Synthesis of 3,3-Spiroindolines via FeCl3-Mediated Cyclization of Aryl- or Alkene-Containing 3-Substituted N-Ac Indoles

We report the cyclization of 3-substituted N-acetylindoles for the straightforward synthesis of 3,3-spiroindolines via the Friedel-Crafts reaction of an appended aryl group or the formal [2 + 2] cycloaddition of an appended alkene. Our strategy involves a

Cu-catalyzed β-functionalization of saturated ketones with indoles: A one-step synthesis of C3-substituted indoles

An effective one-pot synthesis of β-indolylketones from saturated ketones and indoles was developed. It is noteworthy that this methodology has a good functional group tolerance (alkyl, nitro, halogen, hydroxyl, methoxyl, carboxyl and ester) and is of great significance to the preparation of many indole heterocycles.

In situ generation of Iron(iii) dodecyl sulfate as Lewis acid-surfactant catalyst for synthesis of bis-indolyl, tris-indolyl, Di(bis-indolyl), Tri(bis-indolyl), tetra(bis-indolyl)methanes and 3-alkylated indole compounds in water

Iron(iii) dodecyl sulfate as Lewis acid-surfactant catalyst was prepared in situ and effectively used in the synthesis of bis(indolyl)methanes and Michael reactions of indoles with α,β-unsaturated carbonyl compounds in water. Also, this method was used for the synthesis of 1,1,3-tri-indolyl compounds, producing good to excellent yield at room temperature.

Unveiling the reactivity of propargylic hydroperoxides under gold catalysis

Controlled gold-catalyzed reactions of primary and secondary propargylic hydroperoxides with a variety of nucleophiles including alcohols, phenols, 2-hydroxynaphthalene-1,4-dione, and indoles allow the direct and efficient synthesis of β-functionalized ke

Conjugate addition of indoles with electron-deficient olefins catalyzed by Fe-exchanged montmorillonite K10

Conjugate addition of indoles with a variety of electron-deficient olefins in the presence of Fe-exchanged montmorillonite K10 affords the corresponding Michael adduct in excellent yields with high selectivity. The catalyst was also found to be recyclable

InCl3-catalysed conjugate addition of indoles with electron-deficient olefins

Indole and 2-methylindole undergo conjugate addition with electron-deficient olefins in the presence of a catalytic amount of InCl3 at ambient temperature to afford the corresponding Michael adducts in excellent yields with high selectivity.