1175675-37-2

Upstream product

• 36946-70-0 indoleamine 
• 1416983-93-1 1-(3-hydroperoxyprop-1-ynyl)-4-methoxybenzene 
• 7448-86-4 1-(4-methoxyphenyl)prop-2-en-1-one 
• 120-72-9 indole 
• 14006-70-3 3-indol-3-yl-1-(4-methoxy-phenyl)-propan-1-one 
• 5720-07-0 4-methoxyphenylboronic acid 
• 26869-12-5 2-chloro-9H-pyrido[2,3-b]indole 

Relevant academic research and scientific papers

Concise Synthesis of Spiro[indoline-3,2′-pyrrolidine] and 1-Azacarbazole Derivatives via Copper-Catalyzed Cyclization of Indoles

A high-yielding, copper-catalyzed dearomatization reaction of indole from 2-methylindole-derived oxime acetates was realized, providing access to structurally novel spiro[indoline-3,2′-pyrrolidine] derivatives in 67–98% yields. When the C-2 position of the indole was not substituted, azacarbazole derivatives were obtained in moderate yields. This transformation provides an efficient approach to access nitrogen-containing spiroindolenine and azacarbazole derivatives with wide substrate scope. (Figure presented.).

Gold/acid-co-catalyzed direct microwave-assisted synthesis of fused azaheterocycles from propargylic hydroperoxides

The gold-acid-co-catalyzed synthesis of nine series of fused azaheterocycles with structural diversity starting from the same synthons as readily available propargylic hydroperoxides and aromatic amines has been achieved. The overall tandem process consists in a gold-catalyzed hydroperoxide rearrangement/Michael reaction followed by a final acid-catalyzed cyclization.

Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl

The present invention relates to compounds of formula (I) wherein R1, R2 and R3 are as defined in the description, to their pharmaceutical compositions and use thereof for the treatment of cancer expressing oncogenic ALK protein, particularly anaplastic l

Chemoselective functionalization of α-carbolines at the C-2, C-3, C-4, and C-6 positions using Suzuki-Miyaura reactions

The synthesis of 2-, 3-, 4-, and 6-substituted pyrido[2,3-b]indoles (α-carbolines) by palladium-catalyzed cross-coupling reactions from the corresponding halopyrido[2,3-b]indoles is described. A sequential and a one-pot chemoselective double Suzuki-Miyaur