1400633-86-4

Upstream product

• 1400633-76-2 6-(4-fluorophenyl)-2-phenoxymethyl-7,8-dihydro-6H-imidazo[1,2-c]pyrimidin-5-one 
• 1400633-48-8 6-(4-fluorophenyl)-2-phenoxymethyl-6H-imidazo[1,2-c]pyrimidin-5-one 
• 1400633-94-4 2-chloromethyl-6-(4-fluorophenyl)-6H-imidazo[1,2-c]pyrimidin-5-one 
• 1400633-92-2 4-amino-1-(4-fluorophenyl)-1H-pyrimidin-2-one 
• 1400633-46-6 2-phenoxymethyl-6H-imidazo[1,2-c]pyrimidin-5-one 
• 1400633-91-1 7-chloro-2-phenoxymethyl-6H-imidazo[1,2-c]pyrimidin-5-one 
• 1400633-90-0 7-chloro-5-methylsulfanyl-2-phenoxymethylimidazo[1,2-c]pyrimidine 
• 1059191-49-9 7-chloro-2-chloromethyl-5-methylsulfanylimidazo[1,2-c]pyrimidine 
• 1765-93-1 4-fluoroboronic acid 

Relevant academic research and scientific papers

SUBSTITUTED IMIDAZOPYRIMIDIN-5(6H)-ONES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS

In one aspect, the invention relates to imidazopyrimidin-5(6H)-one analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

SUBSTITUTED IMADAZAPYRINIDIN-5(6H)-ONES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS

In one aspect, the invention relates to imidazopyrimidin-5(6H)-one analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.