1400701-95-2

Upstream product

• 625446-22-2 4-bromo-2-fluoroacetophenone 
• 1059549-72-2 methyl 4-acetyl-3-fluorobenzoate 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Downstream Products

• 1400701-94-1 1,1,1-trifluoro-2-[2-fluoro-4-(hydroxymethyl)phenyl]propan-2-ol 

Relevant academic research and scientific papers

SULFONAMIDE COMPOUNDS HAVING TRPM8 ANTAGONISTIC ACTIVITY

Sulfonamide compounds having TRPM8 antagonistic activity are provided. A sulfonamide compound of formula (I) or a pharmaceutically acceptable salt thereof, or a prodrug thereof: (I) wherein Ring A is bicyclic aromatic heterocycle comprised of (a) pyridine is condensed with benzene; or (b) pyridine is condensed with monocyclic aromatic heterocycle, and Ring A binds to a sulfonylamino moiety on a carbon atom adjacent to a nitrogen atom of the pyridine ring constituting Ring A, Ring B is (a) monocyclic or bicyclic aromatic hydrocarbon; (b) monocyclic or bicyclic alicyclic hydrocarbon; (c) monocyclic or bicyclic aromatic heterocycle; or (d) monocyclic or bicyclic non-aromatic heterocycle, Ring C is (a) benzene; or (b) monocyclic aromatic heterocycle, and other symbols are the same as defined in the specification.