1400743-00-1

Basic information

• Product Name: C₁₄H₁₉BBrFO₂
• Synonyms: C₁₄H₁₉BBrFO₂
• CAS NO: 1400743-00-1
• Molecular Weight: 329.017
• Mol File: 1400743-00-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₁₄H₁₉BBrFO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₁₉BBrFO₂(1400743-00-1)
• EPA Substance Registry System: C₁₄H₁₉BBrFO₂(1400743-00-1)

Safety Data

• Hazardous Substances Data: 1400743-00-1(Hazardous Substances Data)

Upstream product

• 59142-68-6 2-bromo-4-fluorobenzaldehyde 
• 1221684-51-0 2-bromo-4-fluoro-1-vinylbenzene 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 

Relevant articles and documents

Development of N-Heterocyclic Carbene-Copper Complexes for 1,3-Halogen Migration

A series of NHC-copper complexes was synthesized and their potential to catalyze 1,3-halogen migration explored. Increasing the steric bulk around the metal drastically improves the lifetime of NHC-CuH species and promotes 1,3-halogen migration of both 2-

Copper-catalyzed recycling of halogen activating groups via 1,3-halogen migration

A Cu(I)-catalyzed 1,3-halogen migration reaction effectively recycles an activating group by transferring bromine or iodine from a sp2 to a benzylic carbon with concomitant borylation of the Ar-X bond. The resulting benzyl halide can be reacted in the same vessel under a variety of conditions to form an additional carbon-heteroatom bond. Cross-over experiments using an isotopically enriched bromide source support intramolecular transfer of Br. The reaction is postulated to proceed via a Markovnikov hydrocupration of the o-halostyrene, oxidative addition of the resulting Cu(I) complex into the Ar-X bond, reductive elimination of the new sp3 C-X bond, and final borylation of an Ar-Cu(I) species to turn over the catalytic cycle.